抗生素联合热炎宁治疗猩红热的有效性及对血清CRP水平的影响  

Efficacy of antibiotics combined with Reyanning in the treatment of scarlet fever and its effect on serum C-reactive protein level

作　　者：张晓芳[1] 郭春艳 张玉凤[1] 杨亚荣[1] 符佳[1] ZHANG Xiaofang;GUO Chunyan;ZHANG Yufeng;YANG Yarong;FU Jia(Department of Infection,Xi\an Children\s Hospital,Shaanxi Xi\an 710003,China;Children Health&Care Center of Yulin Children\s Hospital,Shaanxi Yulin 719000,China)

机构地区：[1]西安市儿童医院感染科,陕西西安710003 [2]榆林市儿童医院儿保中心,陕西榆林719000

出　　处：《中国妇幼健康研究》2020年第5期645-648,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨抗生素联合热炎宁合剂治疗猩红热的有效性及对血清C-反应蛋白(CRP)水平的影响。方法选取2018年3月至2019年3月西安市儿童医院感染科收治的猩红热患儿64例为研究对象,随机分为对照组和研究组,各32例。对照组给予抗生素注射用阿莫西林克拉维酸钾静脉滴注治疗,研究组在此基础上加用热炎宁合剂治疗,比较两组患儿的临床治疗总有效率和不良反应发生情况,并比较治疗前后两组患儿血清CRP水平的变化情况。结果研究组患儿的治疗总有效率显著高于对照组(χ^2=5.379,P<0.05)。研究组患儿不良反应发生率为40.63%,对照组不良反应发生率为28.13%,两组差异无统计学意义(χ^2=1.108,P>0.05)。对照组和研究组治疗后的血清CRP水平均低于治疗前,两组组内治疗前后差异均有统计学意义(t值分别为3.982、6.544,均P<0.05);且治疗后研究组患儿血清CRP水平显著低于对照组(t=2.411,P<0.05)。结论使用抗生素联合热炎宁合剂治疗猩红热能达到更好的临床治疗效果,治疗总有效率更高,联合治疗中不良反应发生情况无明显加重,安全性仍保持在较好的水平,同时患儿血清CRP水平的改善更为显著,患儿机体炎症反应水平明显下降。Objective To explore the efficacy of antibiotics combined with Reyanning in the treatment of scarlet fever and its effect on serum levels of C-reactive protein(CRP) in children. Methods 64 children with scarlet fever admitted to Xi’an Children’s Hospital from March 2018 to March 2019 were selected and randomly divided into control group and research group,with 32 cases in each group. The control group was treated with intravenous drip of amoxicillin potassium clavulanate,and the research group was treated with Reyanning mixture on this basis. The clinical efficacy and adverse reactions of the two groups were compared,and changes of serum CRP level in the two groups before and after treatment were also compared. Results The total effective rate of the research group was significantly higher than that of the control group(χ^2=5.379,P<0.05). There was no significant difference in the incidence of adverse reactions between the research and control group(40.63% vs. 28.13%,χ^2=1.108,P>0.05). The level of serum CRP after treatment in both the control group and the research group were lower than those before treatment,and the differences were statistically significant(t=3.982 and 6.544,respectively,both P<0.05). Moreover,the level of serum CRP after treatment in the study group was significantly lower than that in the control group(t=2.411,P<0.05). Conclusion Antibiotics combined with Reyanning mixture can achieve better clinical therapeutic effect for scarlet fever,with higher total therapeutic efficiency,no significant aggravation of adverse reactions in the combined treatment,and the safety remains at a good level. Meanwhile,the level of serum CRP in children improved more significantly,indicating that the level of inflammation in children has decreased significantly.

关 键 词：抗生素 热炎宁 猩红热 C-反应蛋白 

分 类 号：R725.6[医药卫生—儿科]