黄酮类化合物对血管内皮细胞损伤的保护作用及机制研究进展  

Research Progress of Regulatory Effect and Mechanism of Flavonoids on Vascular Endothelial Cell Injury

作　　者：白鹭 李鸿 覃琴 冯柏林 张良 韦飞燕 杨秀芬 BAI Lu;LI Hong;QIN Qin;FENG Bai-lin;ZHANG Liang;WEI Fei-yan;YANG Xiu-fen({School of Pharmacy Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,南宁530200

出　　处：《中国实验方剂学杂志》2020年第12期203-211,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81960698,81260652,81060353);广西自然科学基金重点项目(2015GXNSFDA139023);广西壮瑶药重点实验室项目(桂科基字[2014]32号);广西中医药大学广西一流学科建设开放课题(2019XK113.2019XK122)。

摘　　要：探讨黄酮类化合物对血管内皮细胞的影响。血管内皮细胞位于血浆与血管组织之间,完成血浆和组织液的代谢交换,合成和分泌多种生物活性物质,从而保证血管正常的收缩和舒张,维持血管张力,其可以调节血压以及凝血与抗凝平衡,保持血液的正常流动和血管的长期通畅。内皮细胞损伤会导致高血压、冠心病等一系列心血管疾病,黄酮类化合物是广泛存在于自然界的一大类化合物,由于这类化合物大多呈黄色或淡黄色,且分子中多含有酮基而被称为黄酮。黄酮类化合物分布广泛,多存在于高等植物和羊齿类植物中。各种黄酮类化合物如黄酮类、黄酮醇类、二氢黄酮类、异黄酮类、黄烷酮类等对血管内皮细胞都有一定的保护作用。本研究通过查阅文献并总结得黄酮类化合物具有抗炎,降低血管的脆性,改善血管的通透性、降低血脂和胆固醇,扩张血管,抗血凝等作用,且具有与植物雌激素相同的作用,可以通过抗炎,抗氧化应激,稳定线粒体功能,调节一氧化氮(NO)的方式减轻血管内皮细胞的损伤,临床上可用于治疗脑供血不足、脑出血所致后遗症、高黏脂血症、脑血栓、冠心病、心绞痛等疾病。To investigate the effect of flavonoid compounds on vascular endothelial cells.Vascular endothelial cells were located between plasma and vascular tissue,and can complete the metabolic exchange of plasma and interstitial fluid,synthesize and secrete a variety of biologically active substances,so as to ensure the normal contraction and relaxation of blood vessels,and maintain the tension of blood vessels.Besides,it can regulate blood pressure and the balance of blood coagulation and anticoagulation,and maintain normal blood flow and long-term patency of blood vessels.Endothelial cell damage can cause a series of cardiovascular diseases,such as hypertension and coronary heart disease.Flavonoids are widely found in nature.Because these compounds are mostly yellow or light yellow,they contain ketone groups in the molecule,which are called flavones.Flavonoids are widely distributed,mostly in higher plants and ferns.Various flavonoid compounds,such as flavonoids,flavonols,flavanones isoflavones and flavanones,can protect vascular endothelial cells.This article reviews relevant findings published in domestic and foreign journals.It is found that flavonoids have effects in resisting inflammation,reducing blood vessel fragility,improving blood vessel permeability,lowering blood lipids and cholesterol,vasodilating and resisting hemagglutinating,with the same effect as phytoestrogens.They can reduce vascular endothelial cell damage through anti-inflammatory,anti-oxidative stress,stable mitochondrial function,and regulating nitric oxide(NO).It can be used in clinic to treat diseases,such as insufficient cerebral blood supply,sequelae caused by cerebral hemorrhage,hyperviscosity,cerebral thrombosis,coronary heart disease and angina pectoris.

关 键 词：黄酮类化合物 血管内皮细胞 机制 研究进展 

分 类 号：R2-0[医药卫生—中医学] R22