基于“产丁酸菌——中药多糖”的中药药理研究进展  

Advances in Pharmacological Research of Traditional Chinese Medicine Based on"Butyric Acid Producing Bacteria-Polysaccharides of Traditional Chinese Medicine"

作　　者：林萍 舒青龙[1] LIN Ping;SHU Qing-long(College of Traditional Chinese Medicine(TCM),Jiangxi University of TCM,Nanchang 330004,China)

机构地区：[1]江西中医药大学中医学院,南昌330004

出　　处：《中国实验方剂学杂志》2020年第12期219-226,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(31560038.81473455);江西省自然科学基金项目(20171BAB205087)。

摘　　要：最新研究表明肠道菌群与中药药理紧密相关,微生态机制研究已成为中药药理研究的新方向。诸多的肠道菌群功能类群中,产丁酸菌是肠道菌群的一个重要功能类群,其能够发酵膳食纤维、碳水化合物、内源蛋白等产生代谢产物,其菌群的失调也与多种疾病的发生相关,因产丁酸菌的重要次级代谢产物是丁酸,而丁酸作为一种重要的短链脂肪酸,在维持肠道健康、调节免疫系统和炎症反应、调节能量代谢、影响细胞分化和凋亡上发挥着重要作用。中药多糖具有含量多、不易被宿主消化吸收但能够被肠道菌群分解利用的特点,可以作为细菌碳源,对包括产丁酸菌在内的肠道菌群进行调节,通过改善肠道菌群结构达到治疗疾病的目的。因此,基于"产丁酸菌--中药多糖"的中药药理研究,从肠道细菌的功能和从菌群碳源的多糖成分研究中药药理,是中药微生态机制研究的新领域,亟待加强。该文结合最新文献和自己中药微生态药理工作,综述了丁酸的作用、产丁酸菌利用中药多糖的分子机制、中药多糖与产丁酸菌关联性等方面的研究进展,探讨了产丁酸菌与中药多糖之间的联系,并对基于"产丁酸菌--中药多糖"的中药药理研究进行了展望,以期抛砖引玉,为基于"产丁酸菌--中药多糖"的中药药理研究进展提供参考。The latest research shows that the intestinal flora is closely related to the pharmacology of traditional Chinese medicine(TCM),and the study of microecological mechanism is a new direction of pharmacology of TCM.Among many functional groups of intestinal flora,butyric acid producing bacteria is an important functional group of intestinal flora.It can ferment dietary fiber,carbohydrate,endogenous protein and so on to produce metabolites.The imbalance of its flora is also related to the occurrence of a variety of diseases.The reason is that butyric acid is an important secondary metabolite of butyrobacteria.As an important short chain fatty acid,butyric acid can maintain intestinal health,regulate immune system and inflammatory response,regulate energy metabolism,and affect cell fraction Chemokines and apoptosis play an important role.Polysaccharide of TCM has the characteristics of high content,not easy to be digested and absorbed by the host,but can be decomposed and utilized by intestinal flora.It can be used as the carbon source of bacteria to regulate the intestinal flora,including butyric acid producing bacteria,and improve the structure of intestinal flora to achieve the purpose of disease treatment.Therefore,based on"butyric acid producing bacteria-polysaccharide of TCM",it is a new field in the study of microecological mechanism of TCM to study the pharmacology of TCM from the function of intestinal bacteria and the polysaccharide component of flora carbon source.Based on the latest literature and microecological pharmacology of TCM,this paper reviews the role of butyric acid,the molecular mechanism of butyric acid producing bacteria using polysaccharide of TCM,the relationship between polysaccharide of TCM and butyric acid producing bacteria,and discusses the relationship between butyric acid producing bacteria and polysaccharide of TCM.It also looks forward to the research of TCM pharmacology based on"butyric acid producing bacteria-polysaccharide of TCM",in order to provide a reference for the research

关 键 词：短链脂肪酸 丁酸 肠道菌群 产丁酸菌 中药多糖 

分 类 号：R2-0[医药卫生—中医学] R285