盐酸坦索罗辛缓释胶囊治疗输尿管下段结石的临床效果观察  

Clinical observation of tamsulosin hydrochloride sustained-release capsules for lower ureteral stones

作　　者：毛智锋 赖鹏 林敬莱 陈凌宇 MAO Zhifeng;LAI Peng;LIN Jinglai(Xiamen Branch,Zhongshan Hospital,Fudan University,Fujian Province,Xiamen 361006,China)

机构地区：[1]复旦大学附属中山医院厦门医院,福建省厦门市361006

出　　处：《临床合理用药杂志》2020年第14期16-17,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察盐酸坦索罗辛缓释胶囊治疗输尿管下段结石的临床效果。方法选取2018年7月-2019年12月复旦大学附属中山医院厦门医院收治的输尿管下段结石患者88例,依据治疗方案不同分为对照和观察组,每组44例。对照组采用双氯芬酸钠双释放肠溶胶囊+硝苯地平片+排石颗粒治疗,观察组在对照组基础上加用盐酸坦索罗辛缓释胶囊治疗。比较2组结石清除情况(治疗后7、14、21、28 d结石排净率及排石时间)、治疗前后疼痛(NRS)评分、国际前列腺症状(IPSS)评分及不良反应(后肾绞痛、腹部疼痛、心率加快)发生率。结果观察组治疗后7、14、21、28 d结石排净率均高于对照组(P<0.05或P<0.01);观察组排石时间为(9.41±2.73)d,短于对照组的(14.66±2.79)d(t=8.922,P<0.01);治疗后,2组NRS、IPSS评分较治疗前均下降,且观察组低于对照组(P<0.01);2组治疗期间不良反应(后肾绞痛、腹部疼痛、心率加快)总发生率比较差异无统计学意义(χ~2=0.124,P>0.05)。结论盐酸坦索罗辛缓释胶囊治疗输尿管下段结石疗效确切,可提高结石清除效率,减轻疼痛,改善患者前列腺症状,不良反应少,安全性高。Objective To observe the clinical efficacy of tamsulosin hydrochloride sustained-release capsules for lower ureteral stones.Methods 88 patients with lower ureteral stones(July 2018 to December 2019)who came to Xiamen Branch,Zhongshan Hospital,Fudan University for treatment were selected and divided into two groups:control(n=44)and observation(n=44)according to different treatment protocols.The control group was treated with diclofenac sodium double-release enteric-coated capsules+nifedipine tablets+Paishi granules,and the observation group was treated with tamsulosin hydrochloride sustained-release capsules.Comparison of stone clearance(calculus removal rate at 7 d,14 d,21 d,and 28 d after treatment,stone discharge time),pain before and after treatment(NRS)score,and international prostate symptoms were compared between the two groups Score(IPSS)score,incidence of adverse reactions(postrenal angina,abdominal pain,accelerated heart rate).Results Compared with the stone removal in the control group,the stone removal rate was higher in the observation group after 7 d,14 d,21 d,and 28 d(P<0.05 or P<0.01).The stone discharge time of the observation group was(9.41±2.73)d,which was shorter than that of the control group(14.66±2.79)d(t=8.922,P<0.01).After treatment,compared with the control group,the observation group had significantly lower NRS and IPSS scores(P<0.01).Adverse reactions during the observation group(retrorenal strangulation),there was no significant difference in the incidence of pain,abdominal pain,and accelerated heart rat(11.36%)compared with the control group(9.09%)(χ~2=0.124,P>0.05).Conclusion Tamsulosin hydrochloride sustained-release capsules are effective in the treatment of lower ureteral stones,can improve the efficiency of stone removal,reduce pain,improve prostate symptoms,and do not significantly increase adverse reactions,and have good safety.

关 键 词：输尿管下段结石 盐酸坦索罗辛缓释胶囊 双氯芬酸钠双释放肠溶胶囊 硝苯地平片 排石颗粒 临床效果 

分 类 号：R693.4[医药卫生—泌尿科学]