冠心病患者hs-CRP、DPP-4水平及其与冠状动脉病变程度的相关性  

Relationship between the levels of hs-CRP,DPP-4 and the degree of coronary artery disease

作　　者：孙春喜[1] 任小鹏[1] 李建成 董喜梅 SUN Chun-xi;REN Xiao-peng;LI Jian-cheng;DONG Xi-mei(First Ward of Department of Internal Medicine-Cardiovascular,Shangluo Central Hospital,Shangluo 726000,Shaanxi,CHINA;Department of Internal Medicine-Cardiovascular,the Sun Simiao Hospital of Beijing University of Traditional Chinese Medicine,Tongchuan 727000,Shaanxi,CHINA)

机构地区：[1]商洛市中心医院心血管内科一病区,陕西商洛726000 [2]北京中医药大学孙思邈医院心血管内科,陕西铜川727000

出　　处：《海南医学》2020年第11期1397-1400,共4页Hainan Medical Journal

摘　　要：目的分析冠心病患者超敏C反应蛋白(hs-CRP)、二肽基肽酶(DPP)-4水平变化及其与冠状动脉病变程度的相关性。方法选取2018年2月至2019年2月商洛市中心医院收治的112例冠心病患者作为观察组,根据患者心脏外科与介入治疗狭窄冠脉研究(SYNTAX)积分将患者分为高危组33例、中危组37例及低危组42例,另选择同期健康体检者60例为正常对照组。检测并比较所有受检者的hs-CRP、DPP-4水平,采用Pearson相关性分析法分析hs-CRP、DPP-4与SYNTAX积分的相关性。结果观察组患者的hs-CRP和DPP-4水平分别为(15.60±2.13) mg/L、(11.79±3.06) ng/L,明显高于正常对照组的(3.82±0.94) mg/L、(6.78±2.14) ng/L,差异均有统计学意义(P<0.05);高危组患者的hs-CRP和DPP-4水平分别为(16.64±2.25) mg/L、(14.81±4.42) ng/L,明显高于中危组的(12.38±1.57) mg/L、(11.23±3.75) ng/L及低危组的(8.25±0.89) mg/L、(7.96±2.31) ng/L,中危组的hs-CRP和DPP-4水平明显高于低危组,差异均有统计学意义(P<0.05);不同冠状动脉病变支数患者中三支病变患者的hs-CRP和DPP-4水平分别为(16.57±1.62) mg/L、(13.96±3.78) ng/L,明显高于双支病变患者的(13.60±1.48) mg/L、(11.79±2.91) ng/L和单支病变患者的(8.62±1.09) mg/L、(9.04±2.32) ng/L,且双支病变患者的hs-CRP和DPP-4水平明显高于单支病变,差异有统计学意义(P<0.05);发生心血管事件的患者hs-CRP和DPP-4水平[(15.38±1.94) mg/L、(13.73±4.01) ng/L]明显高于未发生心血管事件的患者[(10.60±1.24) mg/L、(9.81±2.83) ng/L],差异有统计学意义(P<0.05);冠心病患者的hs-CRP、DPP-4水平均与SYNTAX积分呈正相关(r=0.53、0.61,P<0.05)。结论 hs-CRP和DPP-4水平与冠心病患者的冠状动脉病变程度呈正相关,可用于指导冠心病的病情诊断及预后评估。Objective To analysis the levels of high-sensitivity C-reactive protein(hs-CRP) and dipeptidyl peptidase 4(DPP-4) in coronary heart disease(CHD), and explore their correlation with the degree of CHD. Methods A total of 112 patients with CHD, who admitted to Shangluo Central Hospital from February 2018 to February 2019 were selected as the observation group. According to the score of patients’ heart surgery and SYNTAX(Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery), the patients were divided into the high-risk group(n=33),medium risk group(n=37) and low-risk group(n=42). In addition, 60 healthy people in the same period were selected as the normal control group. The levels of hs-CRP and DPP-4 in all subjects were measured and compared, and the correlation between hs-CRP, DPP-4 and SYNTAX score was analyzed by Pearson correlation analysis. Results The levels of hs-CRP and DPP-4 in the observation group were(15.60±2.13) mg/L,(11.79±3.06) ng/L, respectively, which were significantly higher than corresponding(3.82±0.94) mg/L,(6.78±2.14) ng/L in the normal control group(P<0.05);the levels of hs-CRP and DPP-4 were(16.64±2.25) mg/L and(14.81±4.42) ng/L in high risk group, which were significantly higher than corresponding(12.38±1.57) mg/L and(11.23±3.75) ng/L of the middle risk group and(8.25±0.89) mg/L and(7.96±2.31) ng/L of the low risk group, and the levels of hs-CRP and DPP-4 in the middle risk group were also significantly higher than those in the low risk group(all P<0.05);the levels of hs-CRP and DPP-4 in patients with three lesions were(16.57±1.62) mg/L and(13.96±3.78) ng/L, which were significantly higher than corresponding(13.60±1.48) mg/L and(11.79±2.91) ng/L in patients with two lesions,(8.62±1.09) mg/L and(9.04±2.32) ng/L in patients with single lesions(all P<0.05);the levels of hs-CRP and DPP-4 in patients with two lesions were significantly higher than those in patients with single lesions(P<0.05);the levels of hs-CRP and DPP-4 in patients with cardiovas

关 键 词：冠心病 超敏C反应蛋白 二肽基肽酶-4 冠状动脉病变 预后 

分 类 号：R541.4[医药卫生—心血管疾病]