健康幼儿粪便微生物移植治疗难治性溃疡性结肠炎的疗效观察  

Clinical curative effect of fecal microbial transplantation from healthy infants on complicated ulcerative colitis

作　　者：王兰兰 闵敏 刘岩 毕义亮 徐杨 WANG Lanlan;MIN Min;LIU Yan;BI Yiliang;XU Yang(Department of Gastroenterology,the Fifth Medical Center of PLA General Hospital,Beijing 100071,China)

机构地区：[1]解放军总医院第五医学中心消化内科,北京100071

出　　处：《重庆医学》2020年第11期1754-1758,共5页Chongqing medicine

基　　金：北京市自然科学基金面上项目(7182122)。

摘　　要：目的探讨健康幼儿的粪便微生物移植(FMT)对难以控制或反复复发的难治性溃疡性结肠炎(UC)患者的治疗效果。方法选用患者健康子女的粪便作为供体,参照文献的粪菌分离方法收集粪菌液,通过内镜下均匀喷洒粪菌液观察患者临床转归情况。结果入组的UC患者Mayo评分均在6分以上,在接受激素治疗效果不乐观的状态下通过健康幼儿粪菌移植后临床症状得以控制,血白细胞(WBC)、中性粒细胞(N)、C反应蛋白(CRP)、红细胞动态沉降率(ESR)呈下降趋势,治疗3个月后复查肠镜,结肠黏膜充血水肿及溃疡较治疗前好转,Mayo评分明显下降。结论应用健康幼儿粪菌移植法治疗难以控制或反复复发的UC患者是有效的。Objective To explore the curative effect of fecal microbiota transplantation(FMT)from healthy infants on recurrent or uncontrollable ulcerative colitis(UC).Methods The patient′s healthy infants was selected as a donor,bacterial liquid was collected by referencing to separation method of fecal bacteria.The bacterical solution was sprayed evenly under endoscopy.The clinical outcome was observed.Results UC patients with Mayo score above 6 were enrolled,who controlled poorly after hormone therapy,and their clinical symptoms were alleviated when accepted healthy infant′s fetal transplantation,and the blood leukocytes(WBC),neutrophils(N),hypersensitive C-reactive protein(CRP),dynamic erythrocyte sedimentation rate(ESR)were declined.After 3 months of treatment,colonoscopy showed that the congestion,edema and ulcer of the colonic mucosa were improved,and Mayo score significantly decreased than before.Conclusion Fecal microbiota transplantation(FMT)from healthy infants is effective for recurrent or uncontrollable ulcerative colitis.

关 键 词：结肠炎 溃疡性 难治病 粪菌移植 健康幼儿 临床缓解 结肠黏膜修复 

分 类 号：R322.45[医药卫生—人体解剖和组织胚胎学]