不同病程的哮喘缓解期患儿肺功能及气道反应性特点  

Characteristics of pulmonary function and airway responsiveness in children with asthma remission in different course

作　　者：刘芳君[1] 龚财惠[1] 宋思思[1] 符州[1] 刘莎[1] LIU Fangjun;GONG Caihui;SONG Sisi;FU Zhou;LIU Sha(Pulmonary Function Room,Children′s Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院肺功能室/儿童发育疾病研究教育部重点实验室/国家儿童健康与疾病临床医学研究中心/儿童发育重大疾病国家国际科技合作基地/儿科学重庆市重点实验室,400014

出　　处：《重庆医学》2020年第11期1792-1795,共4页Chongqing medicine

摘　　要：目的观察不同病程的支气管哮喘(简称哮喘)缓解期患儿肺功能及气道反应性的特点。方法选取2018年1-10月在该院哮喘专科门诊随访的哮喘缓解期患儿336例为研究对象,年龄6~14岁,按哮喘病程分为1~<2年组、2~<3年组、3~<4年组、≥4年组,所有患儿行肺通气功能及支气管激发试验(BPT)检测。结果病程1~<4年的3组通气功能类型分布从高到低均为正常、小气道功能障碍、轻度阻塞(P<0.05),3组间通气功能类型的分布无明显差异(P>0.05)。≥4年的患儿轻度阻塞比例明显升高(P<0.05)。各病程组BPT结果无明显差异,阳性患儿比例明显高于阴性(P<0.05),分级均以轻度、极轻度为主(P<0.05)。肺通气功能与BPT结果无相关性(P>0.05)。结论病程是影响哮喘缓解期患儿肺功能的重要因素,4年以上病程的患儿肺功能损害加重,主要表现为轻度阻塞性障碍;气道反应性与病程及肺功能无明显相关性,大部分患儿表现为持续的气道高反应。Objective To investigate the characteristics of pulmonary function and airway responsiveness in children with asthma remission in different disease courses.Methods A total of 336 children in asthma remission stage aged 6 to 14 years old followed up in the asthma outpatient department of this hospital from January to October 2018 were selected and divided into groups of 1≤t<2,2≤t<3,3≤t<4 and t≥4 years according to the disease course(t).Then the pulmonary ventilation function and bronchial provocation test(BPT)were performed in all children.Results The distribution of ventilation function type in the 3 groups with the disease course of 1-4 years was all normal>small airway dysfunction>mild obstruction,from high to low(P<0.05),and there was no significant difference in the distribution of ventilation function type among the 3 groups(P>0.05).The proportion of mild obstruction in children with course≥4 years increased significantly(P<0.05).BPT results of each course group showed no significant difference.The proportion of positive children was significantly higher than that of negative children(P<0.05),and the grades were mainly mild and extremely mild(P<0.05).There was no correlation between pulmonary ventilation function and BPT results(P<0.05).Conclusion Course has an important effect on pulmonary function of children in asthma remission stage.The damage of children with asthma course more than 4 years is aggravated,mainly manifested as mild obstructive lesions.Airway responsiveness was not significantly correlated with the course of disease and pulmonary function.Most children showed persistent airway hyperresponsiveness.

关 键 词：儿童 哮喘缓解期 病程 气道反应性 

分 类 号：R725.6[医药卫生—儿科]