NLR和PLR对AECOPD的诊断价值分析  

Diagnostic value of NLR and PLR level for AECOPD

作　　者：刘于嵩[1] 岑宜静 彭端亮[1] 杜贵鹏 赵鹃[1] 刘成君[3] LIU Yusong;CEN Yijing;PENG Duanliang;DU Guipeng;ZHAO Juan;LIU Chengjun(Clinical Laboratory,Sichuan Academy of Medical Sciences/Sichuan People′s Hospital (East Hospital),Chengdu,Sichuan 610101,China;Department of Critical Medicine,416 Hospital of Nuclear Industry,Chengdu,Sichuan 610051,China;College of Life Sciences,Sichuan University,Chengdu,Sichuan 610101,China)

机构地区：[1]四川省医学科学院·四川省人民医院(东院)检验科,成都610101 [2]核工业四一六医院重症医学科,成都610051 [3]四川大学生命科学院,成都610101

出　　处：《重庆医学》2020年第11期1796-1798,1803,共4页Chongqing medicine

摘　　要：目的探讨血液中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)对慢性阻塞性肺疾病急性加重期(AECOPD)的诊断价值。方法选取70例AECOPD患者(AECOPD组)和116例COPD稳定期患者(COPD组)为研究对象。检测两组患者NLR、PLR、C反应蛋白(CRP)、降钙素原(PCT)水平并进行相关性分析,受试者工作特征曲线(ROC曲线)评估PLR、NLR、CRP及PCT在AECOPD中的诊断价值。结果AECOPD组患者的CRP、NLR、PLR水平明显高于COPD组,差异均有统计学意义(P<0.05)。NLR、PLR、CRP与PCT均呈正相关(r=0.359、0.320、0.797,P<0.001)。CRP的ROC曲线下面积为0.828,NLR的ROC曲线下面积为0.771,PLR的ROC曲线下面积为0.647,PCT的ROC曲线下面积为0.962。结论NLR、PLR可以对AECOPD进行预测诊断,且测试方法简单、成本较低,有较高的临床推广价值。Objective To study the diagnostic value of serum neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR)for acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Data of 70 patients with AECOPD(the AECOPD group)and 116 patients with stable chronic obstructive pulmonary disease(COPD)(the COPD group)were collected.Levels of NLR,PLR,C reactive protein(CRP),calcitonin(PCT)in the two groups were measured and the correlation was analyzed.Receiver operating characteristic curve(ROC curve)was drawn to evaluate the diagnostic value of PLR,NLR,CRP,and PCT for AECOPD.Results The CRP,NLR and PLR levels of patients in the AECOPD group were significantly higher than those in the COPD group,and the differences were statistically significant(P<0.05).NLR,PLR and CRP were positively correlated with PCT(r=0.359,0.320,0.797,P<0.001).The area value under ROC curve of CRP was 0.828,the area value under ROC curve of NLR was 0.771,the area value under ROC curve of PCT was 0.647,and the area value under ROC curve of CRP was 0.962.Conclusion NLR and PLR can predict and diagnose AECOPD,and the method is simple with low cost,which has high clinical popularization value.

关 键 词：肺疾病 慢性阻塞性 C反应蛋白 降钙素原 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 

分 类 号：R563.9[医药卫生—呼吸系统]