清肺排毒汤治疗新型冠状病毒肺炎的临床疗效观察  

Clinical Observation of Qingfeipaidu Decoction in the Treatment of COVID-19

作　　者：王饶琼 杨思进 谢春光[2] 沈其霖 李敏清[4] 雷枭[5] 李继科 黄梅 Wang Raoqiong;Yang Sijin;Xie Chunguang;Shen Qilin;Li Minqing;Lei Xiao;Li Jike;Huang Mei(Traditional Chinese Medicine Hospital Affiliated to South-east Medical University,646000;Affiliated Hospital of Chengdu University of TCM,610036;Mianyang Hospital of TCM,621000;Dazhou Central Hospital,635000;the Affiliated Hospital of North Sichuan Medical College,637000;Public Health Clinical Center of Chengdu,610066;Nanchong Central Hospital,63700)

机构地区：[1]西南医科大学附属中医医院,泸州646000 [2]成都中医药大学附属医院,成都610036 [3]绵阳市中医院,绵阳621000 [4]达州市中心医院,达州635000 [5]川北医学院附属医院,南充637000 [6]成都市公共卫生临床医疗中心,成都610066 [7]南充市中心医院,南充637000

出　　处：《中药药理与临床》2020年第1期13-18,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局《中医药防治新型冠状病毒肺炎应急研究专项课题》;国家中医药管理局治疗新型冠状病毒肺炎临床研究项目四川组。

摘　　要：目的:分析清肺排毒汤治疗新型冠状病毒肺炎的临床疗效。方法:对四川省纳入的98例新型冠状病毒肺炎确诊患者用清肺排毒汤进行3 d为一疗程的治疗,3个疗程后,比较服药前和服药后患者实验室检测指标和中医证候的变化,根据实验室指标及症状的无、轻、中、重程度,给予相应的评分,探讨清肺排毒汤治疗新型冠状病毒肺炎的临床疗效。结果:服用清肺排毒汤3 d后,患者淋巴细胞百分率、天门冬氨酸氨基转移酶和丙氨酸氨基转移酶、D-二聚体恢复正常(P <0. 01),所有患者实验室检查指标正常例数均在70%以上;服用清肺排毒汤6 d后,C反应蛋白和血沉恢复正常(P <0. 01),所有患者实验室检查指标正常例数均在80%以上;服用清肺排毒汤9 d后,所有患者实验室检查指标正常例数均在90%以上。并且CT影像在治疗6 d后好转79人,好转率80%以上。从治疗中医证候积分看,治疗3 d后总有效率为84. 22%,其中痊愈率为21. 14%,显效率为29. 09%,有效率为33. 99%;治疗6 d后总有效率90. 15%,其中痊愈率31. 34%,显效率为30. 15%,有效率为28. 66%;治疗9 d后总有效率92. 09%,其中痊愈率41. 13%,显效率为26. 92%,有效率为24. 04%。结论:清肺排毒汤对于治疗新型冠状病毒肺炎有很好的临床疗效,能显著改善患者的实验室检测异常指标和临床症状,可减少患者不良反应情况,有效提高治疗效果,值得临床推广使用。Objective: To analyze the therapeutic effect of Qingfeipaidu decoction on the treatment of new coronavirus pneumonia in clinical practice. Methods: 98 cases of newly diagnosed coronavirus pneumonia patients in Sichuan province were treated with Qingfeipaidu decoction for3 consecutive courses,each course lasting 3 days. After 3 courses,the changes of laboratory indexes and TCM syndromes of patients before and after treatment were compared. Scores were recorded according to the severity of symptoms( no symptom,mild,general and severe) to investigate the therapeutic effect of Qingfeipaidu decoction on the treatment of new coronavirus pneumonia. Result: After 3 days of the treatment,the levels of lymphocyte percentage,AST,ALT and D-dimer were recovered to normal( P < 0. 01),while laboratory indexes became normal over 70% of the patients. After 6 days of the treatment,C-reactive protein and erythrocyte sedimentation rate( ESR) was recovered to normal( P < 0. 01),while laboratory indexes became normal over 80% of the patients. After 9 days of the treatment,laboratory indexes became normal over 90% of the patients. CT diagnose result showed 79 patients were improved after 6 days treatment,the recovery rate was more than 80%. According to the TCM syndrome scores,after one course of treatment( 3 days),the total effective rate was 84. 22%,among which the recovery rate was 21. 14%,the significant efficiency was29. 09%,and the effective rate was 33. 99%. After two courses of treatment( 6 days),the total effective rate was 90. 15%,among which the recovery rate was 31. 34%,the significant efficiency was 30. 15%,and the effective rate was 28. 66%. After three courses of treatment( 9 days),the total effective rate was 92. 09%,among which the recovery rate was 41. 13%,the significant efficiency was 26. 92%,and the effective rate was 24. 04%. Conclusion: Qingfeipaidu decoction has a good therapeutic effect on the treatment of new coronavirus pneumonia in clinical practice. It significantly improves the abnormal laboratory indexes

关 键 词：清肺排毒汤 新型冠状病毒肺炎 临床疗效 

分 类 号：R259[医药卫生—中西医结合]