丹莪妇康煎膏联合短期GnRH-a治疗对子宫内膜异位症患者术后复发的疗效观察  

Clinical observation on curative effects of Dan’e Fukang Jiangao decoction combined with short-term GnRH-a in treatment of postoperative recurrence of patients with endometriosis

作　　者：张保华[1] 江怡[2] 张善宝[3] 季静[1] 李岚[1] 周小莉 聂启琴 徐红 孙嘉谣 皮衍玲 ZHANG Bao-hua;JIANG Yi;ZHANG Shan-bao;JI Jing;LI Lan;ZHOU Xiao-li;NIE Qi-qin;XU Hong;SUN Jia-yao;PI Yan-ling(Department of Gynaecology and Obstetrics,Punan Hospital of Pudong New area of Shanghai,Shanghai 200125,China;不详)

机构地区：[1]上海市浦东新区浦南医院妇产科,上海200125 [2]上海市浦东新区浦南医院超声科,上海200125 [3]上海市浦东新区浦南医院肾内科,上海200125 [4]上海市浦东新区浦南医院康复科,上海200125

出　　处：《医药论坛杂志》2020年第4期9-12,共4页Journal of Medical Forum

基　　金：上海市浦东新区卫生和计划生育委员会领先人才培养项目(PWRL2018-10)。

摘　　要：目的探讨丹莪妇康煎膏联合短期GnRH-a治疗对预防子宫内膜异位症患者术后复发的临床效果。方法68例患者纳入研究,随机分为研究组和对照组,研究组35例,对照组33例。研究组患者在腹腔镜术后短期GnRH-a治疗3个月,然后应用丹莪妇康煎膏治疗3个月;对照组患者在腹腔镜术后应用维生素E胶丸代替丹莪妇康煎膏。术后6个月及12个月评价疗效,并评估术后6个月停药时药物对患者的不良影响。结果研究组和对照组治疗前后分别进行组内疼痛评分及盆腔包块大小比较,P值均小于0.05,均具有统计学意义;研究组与对照组术后6个月及12个月复发率的比较,P值均小于0.05,具有统计学意义;术后6个月停药时,研究组与对照组kupperman评分比较,P>0.05,无统计学意义。结论丹莪妇康煎膏联合短期GnRH-a治疗可改善子宫内膜异位症患者术后疼痛症状,减少盆腔包块再生,从而提高手术治疗的临床疗效;预防术后复发,且避免长时间应用GnRH-a导致的低雌激素水平引起的不良反应,具有临床上的推广应用价值。Objective To investigate the clinical effect of Dan’e Fukang Jiangao combined with GnRH-a to prevent postoperative recurrence of endometriosis. Methods Totally 68 patients were included in the study and randomly divided into study group and control group,35 cases in the study group and 33 cases in control group. Patients in the study group were treated with GnRH-a after laparoscopic surgery for 3 months,and combined with Dan’e Fukang Jiangao for the next 3 months;in the control group, vitamin E was used instead of Dan’e Fukang Jiangao. Efficacy and adverse effects was assessed 6 month and 12 month after surgery. Results Intra-group pain scores and pelvic mass size were compared before and after treatment in study group and control group, P<0.05, which were statistically significant. Comparison of recurrence rate between study group and control group, P<0.05 was statistically significant. At the drug is discontinued 6 months after surgery, In comparison with control group, the differences of kupperman scores in study group showed no statistical significance, P>0.05. Conclusion Dan’e Fukang Jiangao combined with short-term GnRH-a can improve postoperative pain symptoms in patients with endometriosis and inhibit growth of pelvic mass, so as to improve the clinical efficacy and prevent postoperative recurrence, and to reduce adverse reaction caused by low estrogen level during the combined medication. So it is worthy of extended clinical application.

关 键 词：子宫内膜异位症 腹腔镜术后 丹莪妇康煎膏 GNRH-A 联合治疗 

分 类 号：R711.71[医药卫生—妇产科学]