北京市两家美沙酮维持治疗门诊在治人员肝炎病毒感染状况  

Investigation on hepatitis virus infection in patients in two methadone maintenance treatment clinics in Beijing

作　　者：张嘉翔 刘瑶瑶[2] 李倩[2] 马建新[2] 葛申[2] 丁海峰[2] 张卫[3] 张政[2] ZHANG Jia-xiang;LIU Yao-yao;LI Qian;MA Jian-xin;GE Shen;DING Hai-feng;ZHANG Wei;ZHANG Zheng(Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,太原030001 [2]北京市朝阳区疾病预防控制中心 [3]北京市疾病预防控制中心

出　　处：《首都公共卫生》2020年第2期82-85,共4页Capital Journal of Public Health

基　　金：北京市科技重大专项(编号:D171100003117002);艾滋病和病毒性肝炎等重大传染病防治科技重大专项(编号:2018ZX10715-005)。

摘　　要：目的了解北京市美沙酮维持治疗(methadone maintenance treatment,MMT)门诊在治人员肝炎病毒感染状况。方法2018年4-6月调查北京市第一和第二MMT门诊186名在治人员,采血检测甲型肝炎病毒(HAV)、乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)、戊型肝炎病毒(HEV)感染相关的主要血清学标志物并计算阳性率,比较不同特征调查对象HBV和HCV RNA感染状况差异。结果抗-HAV IgG、抗-HAV IgM阳性率分别为98.9%和1.1%;HBsAg、抗-HBs、抗-HBc的阳性率分别为4.8%、48.9%和63.4%;抗-HCV和HCV RNA阳性率分别为81.5%和48.0%;抗-HEV IgG和抗HEV IgM阳性率分别为6.5%和0.5%。结论MMT门诊在治人群HAV、HBV、HCV三种肝炎病毒感染率高于普通人群,HEV感染率低于普通人群。Objective To understand the status of hepatitis virus infection among the patients in Beijing methadone maintenance treatment(MMT)clinics.Methods From April to June 2018,186 patients of the first and second methadone maintenance treatment clincs in Beijing were investigated.Blood samples were collected to detect major serological markers related to hepatitis A,hepatitis B,hepatitis C and hepatitis E virus infection.The positive rates of major serological markers were calculated,and the differences of HBV and HCV RNA infection status among the subjects with different characteristics were compared.Results The positive rates of anti-HAV IgG and anti-HAV IgM were 98.9%and 1.1%,respectively.The positive rates of HBsAg,anti-HBs,and anti-HBc were 4.8%,48.9%,and 63.4%,respectively.The positive rates of anti-HCV and HCV RNA were 81.5%and 48.0%,respectively.The positive rates of anti-HEV IgG and anti-HEV IgM were 6.5%and 0.5%,respectively.Conclusions The infection rate of hepatitis virus A,B and C in MMT clinic is higher than that of the general population,and the infection rate of hepatitis E is lower than that of the general population.

关 键 词：肝炎病毒属 血清流行病学研究 丙型肝炎病毒RNA 美沙酮维持治疗 乙肝表面抗原 

分 类 号：R512.6[医药卫生—内科学]