CD4+CD25+调节性T细胞及IL-17与老年糖尿病视网膜病变的相关性研究  

Correlation between CD4+ CD25 + Regulatory T Cells and IL-17 and Elderly DR

作　　者：郝兰香 毕建华 黄飞 胥柯 张建 胡海涛 Hao Lanxiang;Bi Jianhua;Huang Fei(Yancheng First People's Hospital,Yancheng,Jiangsu 224005,China)

机构地区：[1]盐城市第一人民医院,江苏盐城224005

出　　处：《四川医学》2020年第4期366-370,共5页Sichuan Medical Journal

摘　　要：目的探讨CD4+CD25+调节性T细胞在老年糖尿病视网膜病变(DR)患者中的水平及意义。方法选取2012年1月至2018年2月在我院治疗的DR患者100例(DR组),同时选取无视网膜病变的单纯糖尿病患者100例作为对照(DM组),检测两组CD4+、CD8+、CD4+CD25+调节性T细胞及IL-17水平。结果 DR组CD4+和CD8+T细胞分别为(26.83±3.22)%和(20.01±3.04)%,明显低于DM组,CD4+CD25+T细胞和IL-17分别为(4.50±1.22)%和(34.49±4.33)ng/m L,明显高于DM组,差异有统计学意义(P <0.05);增殖型DR患者CD4+和CD8+T细胞分别为(25.03±3.11)%和(19.03±3.00)%,明显低于非增殖型DR组,而CD4+CD25+T细胞和IL-17分别为(5.23±1.48)%和(38.82±5.02) ng/m L,明显高于非增殖型DR组(P<0.05);DR患者空腹血糖与CD4+、CD8+、IL-17水平平无明显相关性(P>0.05),空腹血糖与CD4+CD25+T细胞呈负相关(r=-0.169,P=0.017)。结论老年DR患者CD4+和CD8+T细胞水平降低,而CD4+CD25+T细胞水平升高,可能在疾病进展中有重要作用,同时CD4+CD25+T细胞与患者空腹血糖可能有一定的相关性。Objective To explore the level and significance of CD4+ CD25+ regulatory T cells in elderly patients with diabetic retinopathy( DR).Methods 100 patients with diabetes and retinopathy( DR) treated in our hospital from January 2012 to February 2018 were selected( DR group),and 100 patients with simple diabetes without retinopathy were selected as controlgroup( DM group).CD4+,CD8+,CD4+ CD25+ regulatory T cells and IL-17 levels.Results CD4+ and CD8+ T cells in DR group were( 26.83 ± 3.22) % and( 20.01 ± 3.04) %,which were significantly lower than those in DM group.CD4+ CD25+ T cells and IL-17 were( 4.50±1.22) % and( 34.49± 4.33) ng/m L,significantly higher than the DM group( P< 0.05);CD4 + and CD8 + T cells of proliferative DR patients were( 25.03 ± 3.11) % and( 19.03 ± 3.00) %,respectively,which was significantly lower than non-proliferation CD4+ CD25+ T cells and IL-17 were( 5.23 ± 1.48) % and( 38.82 ± 5.02) ng/ml,respectively,which was significantly higher than that of non-proliferative DR group( P< 0.05).There was no significant correlation between blood glucose and CD4+,CD8+ and IL-17 levels( P> 0.05).Fasting blood glucose was negatively correlated with CD4 + CD25 + T cells( r =-0.169,P =0.017).Conclusion In elderly DR patients,the levels of CD4+ and CD8+ T cells decrease,while the increase of CD4+ CD25+ T cells may play an important role in disease progression.At the same time,CD4+ CD25+ T cells may have a certain correlation with fasting blood glucose.

关 键 词：CD4+CD25+T细胞 糖尿病 糖尿病视网膜病变 老年 

分 类 号：R259[医药卫生—中西医结合]