新型毒品“火狐狸”针剂的GC-MS及GC/FID检验研究  

Identifi cation of 5-Methoxy-N,N-diisopropyltryptaminein Injection with GC-MS and GC/FID

作　　者：庄顺[1] 林葭 叶树海 李薇 李航麒[1] 林坚[1] ZHUANG Shun;LIN Jia;YE Shuhai;LI Wei;LI Hangqi;LIN Jian(Forensic Science Division of Fujian Provincial Security Department,Fuzhou 350003,China)

机构地区：[1]福建省公安厅刑事技术总队,福州350003

出　　处：《刑事技术》2020年第3期263-265,共3页Forensic Science and Technology

摘　　要：目的建立N,N-二异丙基-5-甲氧基色胺(5-MeO-DiPT,俗称火狐狸)针剂(无针针筒给药器内液体)的GC-MS定性及GC/FID定量分析方法。方法疑似含毒品针剂样品用乙酸乙酯提取,乙酸乙酯提取液浓缩至干,残渣溶解后用GC-MS及GC/FID进行检测。结果测得未知组分的(tR=13.81min)质谱特征碎片峰信息为m/z114(基峰)、274、174、160、145、130、117、72、43。经与标准物质5-MeO-DiPT的保留时间和质谱图比对,确定为N,N-二异丙基-5-甲氧基色胺。查阅资料对质谱图谱裂解机制进行推断解析。建立GC/FID定量分析方法,线性范围为20~500mg/L,三种添加浓度平均回收率85%以上。结论文章建立的定性定量分析方法简易可靠,适用于含N,N-二异丙基-5-甲氧基色胺针剂液体的检验鉴定。Objective To establish a method for analysis of 5-methoxy-N,N-diisopropyltryptamine(5-MeO-DiPT,sometimes called the Foxy,usually kept in aqueous solution within needleless syringe)with GC-MS and GC/FID.Methods The sample,suspected of containing drug in its aqueous solution with a needleless syringe,was extracted with ethyl acetate,having the extract concentrated and afterwards analyzed with GC-MS and GC/FID.Results An unknown component presented characteristic fragment ion peaks at m/z 114(base peak),274,174,160,145,130,117,72,43,showing well-matched to the reference substance of 5-MeO-DiPT with both the retention time and characteristic fragment ion peaks.Thus,the drug in the injection was tentatively identified as 5-MeO-DiPT.The mechanism of the above-mentioned fragment of characteristic mass-spectrum peak was inferred by reference to relevant literatures.The standard curve was linear from 20mg/L to 500mg/L with the relating coeffi cient of 0.9999 and average recoveries more than 85%.Conclusion The method established here is simple,reliable and suitable for identifi cation of 5-MeO-DiPT in aqueous solution.

关 键 词：法医毒物学 N N-二异丙基-5-甲氧基色胺 火狐狸 GC-MS GC/FID 断裂方式 

分 类 号：DF795.1[医药卫生—法医学]