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作 者:冉飞 张定堃[1] 慈志敏[1] 许润春[1] 韩丽[1] RAN Fei;ZHANG Ding-kun;CI Zhi-min;XU Run-chun;HAN Li(Pharmacy College,Chengdu University of Traditional Chinese Medicine,Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Resources Co-founded by Sichuan Province and Ministry of Science and Technology,Chengdu 611137,China)
机构地区:[1]成都中医药大学药学院,中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都611137
出 处:《中国药学杂志》2020年第10期794-798,共5页Chinese Pharmaceutical Journal
基 金:国家自然科学基金面上项目资助(81773918);成都中医药大学中药学学科特色创新科研团队资助(CXTD2018006)。
摘 要:复合辅料通过对多种辅料结构与功能的重组,在流动性、紧实性、稀释性、压缩性等方面得以增强,成为优质药物制剂高质量高水平发展的重要基础,也是未来辅料工业发展的重要方向。笔者综述了复合辅料的发展历程、技术优势、影响因素、设计原则、制备方法,总结了复合辅料的工业化开发现状,以期为新时代复合辅料的研制开发提供参考。Co-processed excipients are enhanced in terms of fluidity,compactness,dilution,and compressibility by restructuring the structure and function of various excipients,which has become an important basis for the high quality and high level development of high quality pharmaceutical preparations,and also an important direction for the future development of excipient industry.This paper mainly summarizes the development history,technological advantages,influencing factors,design principles,preparation methods of co-processed excipients,and summarizes the current situation of industrial development of co-processed excipients,which provides a reference for the in-depth study of composite excipients.
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