雷火灸联合止吐剂预防妇科肿瘤患者铂类化疗引起的恶心呕吐疗效观察  

Efficacy of hunder-fire moxibustion in prevention of chemotherapy induced nausea and vomiting in gynecological malignant tumors patients treated with platinum-based chemotherapy

作　　者：潘琦津 韦燕 龚建忠 陈彦帆 赵善琳 戴月映 黄连云 刘永燕 PAN Qijin;WEI Yan;GONG Jianzhong;CHEN Yanfan;ZHAO Shanlin;DAI Yueying;HUANG Lianyun;LIU Yongyan(The People’s Hospital of Guigang City, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi, China)

机构地区：[1]广西医科大学第八附属医院贵港市人民医院,广西贵港537100

出　　处：《现代中西医结合杂志》2020年第18期1948-1951,1956,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广西贵港市科学研究与技术开发计划项目(贵科攻1803009)。

摘　　要：目的探讨雷火灸联合止吐剂预防妇科恶性肿瘤患者接受含铂类药物化疗引起的恶心呕吐的有效性。方法采用单中心、前瞻性、非盲法随机对照的研究方法,将接受铂类为基础化疗的妇科恶性肿瘤患者按1∶1的比例随机进入雷火灸组和对照组。对照组使用盐酸昂丹司琼联合地塞米松预防恶心呕吐,雷火灸组使用盐酸昂丹司琼联合地塞米松及雷火灸预防恶心呕吐。记录2组患者入组时一般情况及每日恶心情况、呕吐次数、使用解救药物情况等,化疗第1—5天使用100 mm水平视觉模拟评分尺对患者恶心呕吐状况进行评分。主要研究终点为完全缓解率,次要研究终点包括急性期完全缓解率、延迟期完全缓解率、完全保护率、完全控制率。结果共入组患者80例,雷火灸组和对照组各40例,2组患者年龄、体质量、ECOG体力状况评分、有无吸烟、有无饮酒、肿瘤类型、化疗性质、化疗方案及铂类药物选择情况比较差异均无统计学意义(P均>0.05)。雷火灸组完全缓解率、急性期完全缓解率、延迟期完全缓解率、完全保护率、完全控制率分别为82.5%(33/40),92.5%(37/40),87.5%(35/40),45.0%(18/40),27.5%(11/40),对照组分别为67.5%(27/40),95.0%(38/40),67.5%(27/40),40.0%(16/40),25.0%(10/40),雷火灸组延迟期完全缓解率明显高于对照组(P<0.05),2组其他指标比较差异均无统计学意义(P均>0.05)。结论雷火灸可预防妇科恶性肿瘤患者接受含铂类药物化疗引起的恶心呕吐,其主要提高延迟期完全缓解率,减少迟发性呕吐的发生,为临床上防治恶心呕吐提供了可行方法。Objective It is to assess the efficacy of thunder-fire moxibustion combined with antiemetic in prevention of chemotherapy induced nausea and vomiting(CINV)in gynecological malignant tumors patients treated with platinum-based chemotherapy.Methods The patients with gynecological malignant tumors receiving platinum-based chemotherapy were randomly entered into the thunder-fire moxibustion group and the control group at a 1∶1 ratio through a single-center,prospective,non-blind randomized controlled research method.The control group was treated with ondansetron hydrochloride combined with dexamethasone to prevent CINV,while the thunder-fire moxibustion group received combination of thunder-fire moxibustion,ondansetron hydrochloride and dexamethasone to prevent CINV.The general condition,daily nausea,number of vomiting,use of rescue drugs and so on of the patients in both groups were recorded at the time of enrollment,and nausea and vomiting of all the patients were evaluated by a 100-mm visual analogue scale(VAS)on the 1st to 5th day of chemotherapy.The primary endpoints was the rate of complete response,the secondary endpoints included complete response in the acute and delayed period,complete protection rate and complete control rate.Results A total of 80 cases were enrolled in the group,including 40 cases in the thunder-fire moxibustion group and 40 cases in the control group.There was no statistically significant difference in age,body mass,ECOG performance status score,smoking,drinking,tumor type,chemotherapy type,chemotherapy regimen,and platinum drug selection between the two groups(all P>0.05).The complete remission rate,complete remission rate in the acute phase,complete remission rate in the delayed phase,complete protection rate,and complete control rate in the thunderfire moxibustion group were 82.5%(33/40),92.5%(37/40),87.5%(35/40),45.0%(18/40),27.5%(11/40),respectively,those in the control group were 67.5%(27/40),95.0%(38/40),67.5%(27/40),40.0%(16/40),25.0%(10/40),respectively.The complete remission r

关 键 词：妇科恶性肿瘤 化疗 雷火灸 恶心 呕吐 

分 类 号：R453[医药卫生—治疗学]