血清EPO、TGF-β1、细胞间黏附分子-1与Ⅱ度烧伤患者创面愈合及瘢痕程度的关系分析  

Analysis of the Relationship Between Serum EPO,TGF-β1,Intercellular Adhesion Molecule-1 and Wound Healing and Scar Degree in Patients with Second Degree Burns

作　　者：刘霞[1] 李凯琳 张梦莲 LIU Xia;LI Kai-lin;ZHANG Meng-lian(Department of Burn and Plastic Surgery,the First People's Hospital of Ziyang,Ziyang 641300,Sichuan,China)

机构地区：[1]资阳市第一人民医院烧伤整形科,四川资阳641300

出　　处：《中国美容医学》2020年第6期101-105,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探究血清促红细胞生成素(EPO)、转化生长因子-β1(TGF-β1)、细胞间黏附分子-1(ICAM-1)与Ⅱ度烧伤患者创面愈合及瘢痕程度的关系。方法:选取笔者医院2017年5月-2019年5月收治的Ⅱ度烧伤患者84例作为研究对象,对比不同血清EPO、TGF-β1、ICAM-1水平患者创面愈合时间、创面愈合率及温哥华瘢痕量表(Vancouver scar scale,VSS)评分,Pearson相关性分析血清各指标与创面愈合时间、VSS评分关联性。结果:血清TGF-β1、EPO高表达者创面愈合时间短于低表达者,创面愈合率高于低表达者;ICAM-1高表达者创面愈合时间长于低表达者,创面愈合率低于低表达者,差异均有统计学意义(P<0.05)。血清EPO、TGF-β1与创面愈合时间呈负相关,与创面愈合率呈正相关,ICAM-1与创面愈合时间呈正相关,与创面愈合率呈负相关(P<0.05)。血清EPO高表达者色泽、厚度、血管分布、柔软度评分低于低表达者,TGF-β1高表达者色泽、厚度、血管分布、柔软度评分高于低表达者(P<0.05);血清EPO与瘢痕色泽、厚度、血管分布、柔软度评分呈负相关,TGF-β1与瘢痕色泽、厚度、血管分布、柔软度评分呈正相关(P<0.05)。不同血清ICAM-1水平患者色泽、厚度、血管分布、柔软度评分无比较差异无统计学意义(P>0.05)。结论:血清EPO、TGF-β1、ICAM-1与Ⅱ度烧伤患者创面愈合时间、创面愈合率显著相关,且血清EPO、TGF-β1与创面瘢痕形成密切相关,调控三者表达可能为烧伤患者创面高质量愈合提供了一个潜在干预思路。Objective To investigate the relationship between serum erythropoietin(EPO),transforming growth factor-β1(TGF-β1),intercellular adhesion molecule-1(ICAM-1)and wound healing and degree of scarring in patients with second degree burns.Methods A total of 84 patients with second degree burns treated in our hospital from May 2017 to May 2019 were selected as the research objects.Compare the wound healing time,wound area healing rate and the Vancouver scar scale(VSS)score of patients with different serum EPO,TGF-β1,and ICAM-1 levels.Pearson correlation analysis was used to analyze the correlation of serum indexes with wound healing time and VSS score.Results The serum TGF-β1 and EPO high expression patients had shorter wound healing time than those with low expression.The wound healing time of ICAM-1 high expression was longer than that of low expression,and the wound healing rate was lower than that of low expression(P<0.05).Serum EPO and TGF-β1 were negatively correlated with wound healing time and positively correlated with wound area healing rate,ICAM-1 was positively correlated with wound healing time and negatively correlated with wound area healing rate(P<0.05).Those with high serum EPO expression had lower color,thickness,blood vessel distribution,and softness scores than those with low expression,and those with high expression of TGF-β1 had higher color,thickness,blood vessel distribution,and softness scores than those with low expression(P<0.05).Serum EPO was negatively correlated with scar color,thickness,blood vessel distribution,and softness score,and TGF-β1 was positively correlated with scar color,thickness,blood vessel distribution,and softness score(P<0.05).There was no significant difference in color,thickness,vascular distribution and softness scores among patients with different serum ICAM-1 levels(P>0.05).Conclusion Serum EPO,TGF-β1,ICAM-1 are significantly correlated with wound healing time and wound area healing rate in patients with second degree burns.In addition,serum EPO and TGF-β1 a

关 键 词：促红细胞生成素 转化生长因子-β1 细胞间黏附分子-1 Ⅱ度烧伤 创面愈合 瘢痕 

分 类 号：R644[医药卫生—外科学]