不同剂量羟考酮预防七氟烷全身麻醉小儿术后躁动的效果比较  

Study of the effectiveness of different doses of oxycodone on agitation in children during analepsia period anesthetized by sevoflurane

作　　者：陈红芽 王古岩 宋晓丽[1] 杨洋 CHEN Hong-ya;WANG Gu-yan;SONG Xiao-li;YANG-Yang(Department of Anesthesiology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院麻醉科,北京100730

出　　处：《临床药物治疗杂志》2020年第5期70-73,共4页Clinical Medication Journal

摘　　要：目的比较不同剂量羟考酮用于预防七氟烷全身麻醉小儿术后躁动的效果。方法选择2019年8~11月于北京同仁医院择期行斜视手术的患儿为研究对象,根据羟考酮使用剂量的不同将患儿分为2组,即A组采用羟考酮0.1 mg/kg,B组采用羟考酮0.05 mg/kg。2组患儿均以七氟烷常规全麻,诱导后将羟考酮静脉泵入。分别记录2组患儿的手术时间、七氟烷吸入时间、术后躁动评分、镇痛评分、睁眼时间、恢复室停留时间及不良反应发生率。结果共入选患儿80例,A组和B组各40例。A组患儿的术后躁动发生率为10.0%,低于B组的32.5%(P<0.05)。A组患儿的镇痛满意率为95.0%,高于B组的75.0%(P<0.05)。2组患儿其他各项指标比较,差异均无统计学意义(均P>0.05)。结论与0.05 mg/kg羟考酮用量相比,0.1 mg/kg羟考酮用于预防七氟烷全身麻醉小儿术后躁动中效果更好,镇痛更满意。Objective This study was designed to compare the effects of different doses of oxycodone on agitation in children during analepsia period anesthetized by sevoflurane.Methods Pediatric patients undergoing elective strabismus surgery from August to November in 2019 of Beijing TongrenHospital were selected.They were randomly divided into two groups according to different doses of oxycodone:0.1 mg/kg oxycodone group(group A)and 0.05 mg/kg group(group B).Each patient was generally anesthetized by sevoflurane.After the inhalation,oxycodone was injected by pump control.Data were recorded including operating time,sevoflurane inhalation time,pediatric anesthesia emergence delirium score,pain score,consciousness recovery time,Postanesthesia care unit(PACU)stay time and the incidence of adverse reactions.Results A total of 80 patients were selected,40 patients in group A and 40 patients in group B.The rate of emergent agitation of group A was 10.0%,which was lower than that of group B(32.5%)(P<0.05).The rate of analgesia satisfaction of group A was 95.0%,which was higher than that of group B(75.0%)(P<0.05).There was no significant difference in any other outcome measures(P>0.05).Conclusion Compared with the dose of 0.05 mg/kg oxycodone,the dose of 0.1 mg/kg oxycodone has a better effect on agitation and analgesia during analepsia period in children anesthetized by sevoflurane.

关 键 词：羟考酮 术后躁动 七氟烷 小儿 

分 类 号：R614[医药卫生—麻醉学] R779.7[医药卫生—外科学]