HLA基因多态性与生殖系统疾病及不良妊娠关系的研究进展  

Advances in Research on Relationship between HLA Gene Polymorphism and Reproductive System Diseases and Adverse Pregnancy

作　　者：刘浏 王惠莹 罗加欢 周宁 张媛媛 张若鹏 LIU Liu;WANG Huiying;LUO Jiahuan;ZHOU Ning;ZHANG Yuanyuan;ZHANG Ruopeng(Clinical Medicine of Dali University,Dali 671000,China;The First Affiliated Hospital of Dali University,Dali 671000,China;Institute of Reproductive Medicine,Dali University,Dali 671000,China)

机构地区：[1]大理大学临床医学院,云南大理671000 [2]大理大学第一附属医院生殖医学科,云南大理671000 [3]大理大学生殖医学研究所,云南大理671000

出　　处：《医学综述》2020年第12期2300-2304,2311,共6页Medical Recapitulate

基　　金：国家自然科学基金(81860271);云南省医学学科带头人培养对象(云卫科教发〔2018〕2号文件D-2017020);云南省地方本科高校基础研究联合专项项目(2017FH001-078);大理大学第一附属医院第二批院级重点学(专)科建设项目(201646);大理大学第八批中青年学术带头人后备人才(理大研发〔2017〕2号);大理大学生殖医学创新团队(ZKLX2019320);云南省“万人计划”名医专项(云卫人发〔2019〕35号)。

摘　　要：人类白细胞抗原(HLA)是人类主要组织相容性复合体的产物,本质是具有高度多态性的同种异体抗原,按分布和功能分为Ⅰ类和Ⅱ类抗原,HLA-Ⅰ类抗原由HLA-A、B、C位点编码,HLA-Ⅱ类抗原受控于HLA-D区(包含DP、DM、DO、DQ和DR 5个亚区),且均为具有共显性的多态性位点。HLA系统是目前已知的人体最复杂的多态系统,HLA基因多态性与生殖系统疾病如宫颈癌、生殖道感染、非梗阻性无精子症、隐睾症以及不良妊娠(如免疫性不孕不育、反复种植失败、复发性流产)等相关,在疾病诊断、治疗、疗效评价、预后等方面具有重要价值。Human lymphocyte antigen(HLA)is the product of human major histocompatibility complex,which is a highly polymorphic alloantigen.It can be divided into class I and class II antigens according to its distribution and function.HLA class I antigen is encoded by HLA-A,B and C loci.HLA class II antigen is controlled in HLA-D region(including DP,DM,DO,DQ and DR subregions),all of them which have dominant polymorphic loci.HLA system is the most complex polymorphic system known in human body.HLA gene polymorphisms are related to reproductive system diseases such as cervical cancer,genital tract infection,non-obstructive azoospermia,cryptorchidism and adverse pregnancy(such as immune infertility,repeated implant failure,recurrent abortion),which are of great value in the disease diagnosis,treatment,efficacy evaluation and prognosis.

关 键 词：生殖系统疾病 人类白细胞抗原 不良妊娠 基因多态性 

分 类 号：R71[医药卫生—妇产科学] R321[医药卫生—临床医学]