阻塞性睡眠呼吸暂停综合征型高血压的研究进展  

Research Progress of Obstructive Sleep Apnea Syndrome Hypertension

作　　者：陈甘潇 夏豪[1] CHEN Ganxiao;XIA Hao(Department of Cardiology,Wuhan University People′s Hospital,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心血管内科,武汉430060

出　　处：《医学综述》2020年第12期2420-2424,2429,共6页Medical Recapitulate

基　　金：国家自然科学基金面上项目(81270184)。

摘　　要：阻塞性睡眠呼吸暂停综合征(OSAHS)是一种病因尚不明确的睡眠呼吸疾病,通过夜间睡眠状态下反复出现低通气、呼吸暂停、低氧血症等一系列病理状态,引发相关激素的变化、自主神经的调节紊乱、内皮功能障碍及炎症反应等,最终导致一系列心脑血管疾病,甚至出现猝死。以OSAHS相关高血压为代表的并发症,存在极高的发病率,但早期不易诊断,易漏诊,延误治疗。而OSAHS型高血压与原发性高血压的发病机制存在差异,目前OSAHS型高血压的病理机制尚不完全清楚,未来了解OSAHS型高血压的产生机制可为疾病的诊断及治疗提供帮助。Obstructive sleep apnea syndrome(OSAS)is a sleep respiratory disease with unclear etiology.Through repeated episodes of hypopnea,apnea,hypoxemia and other pathological conditions during nighttime sleep,it induces changes in hormones,autonomy neurological regulation disorders,endothelial dysfunction and inflammatory reactions,eventually leads to a series of cardiovascular and cerebrovascular diseases,and even sudden death.The complications represented by OSAS-related hypertension have very high incidences,but it′s difficult to diagnose early,easy to miss diagnosis and delay treatment.The pathogenesis and physiological mechanism of OSAS hypertension,different from the essential hypertension,are not fully understood,the understanding of which will surely provide help to the diagnosis and treatment in the future.

关 键 词：阻塞性睡眠呼吸暂停综合征 高血压 耐药性高血压 血压变异性 

分 类 号：R544.1[医药卫生—心血管疾病]