聚对氨基苯磺酸/石墨烯电化学修饰电极检测药物中氧氟沙星  

Determination of Ofloxacin in Medicine via Poly(p-aminobenzene sulfonic acid)/Graphene Electrochemical Modified Electrode

作　　者：司晓晶 朱文菁 李香 李丽[3] 陈子超 丁亚萍[3] SI Xiaojing;ZHU Wenjing;LI Xiang;LI Li;CHEN Zichao;DING Yaping(Department of Food Science,Shanghai Business School,Shanghai 200235,China;Experimental Center,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Chemistry,Shanghai University,Shanghai 200444,China)

机构地区：[1]上海商学院食品系,上海200235 [2]山东中医药大学实验中心,济南250355 [3]上海大学化学系,上海200444

出　　处：《应用化学》2020年第6期726-732,共7页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(21671132);山东省重点研发计划(2019GSF108253);上海市属高校应用型本科试点专业建设项目(第六批)资助。

摘　　要：基于石墨烯纳米材料和循环伏安法技术制备了聚对氨基苯磺酸/石墨烯修饰电极并研究了氧氟沙星(OFL)在该修饰电极上的电化学行为,建立了一种简单快速灵敏测定氧氟沙星的电化学分析方法。结果表明,与玻碳电极相比,对氨基苯磺酸/石墨烯电化学修饰电极能显著提高氧氟沙星的峰电流。在优化条件下,其检测线性范围为1~600μmol/L,最低检测限为(S/N=3)0.33μmol/L。该修饰电极具有较好的重现性和稳定性,用于实际样品氧氟沙星滴眼液的测定,效果良好。A simple,rapid and sensitive electrochemical analysis method with a poly(p-aminobenzene sulfonic acid)/graphene modified glassy carbon electrode(pABSA/GR/GCE)for the determination of ofloxacin(OFL)is established based on GR nanomaterials and cyclic voltammetry(CV)in this study.Compared with the glassy carbon electrode,the peak current of OFL increases significantly using pABSA/GR/GCE.Under optimized experimental conditions,the pABSA/GR/GCE shows a good linear relationship with the concentration of OFL in the range of 1~600μmol/L and a detection limit(S/N=3)of 0.33μmol/L.The pABSA/GR/GCE is easy to be prepared with good reproducibility and stability.It has been used in the determination of ofloxacin eye drops with satisfactory results.

关 键 词：石墨烯 对氨基苯磺酸 修饰电极 氧氟沙星 

分 类 号：O657[理学—分析化学]