影响降调节后激素替代周期冷冻胚胎移植结局的相关因素分析  

Analysis of related factors influencing the outcome of hormone replacement cycle frozen embryo transfer after down-regulation

作　　者：柳倩茹[1] 马文敏[1] 陈孟循[1] 黄绮云[1] LIU Qianru;MA Wenmin;CHEN Mengxun;HUANG Qiyun(Assisted Reproduction Center,Foshan Maternal and Child Health Hospital,Foshan 528000,Guangdong,China)

机构地区：[1]佛山市妇幼保健院辅助生殖中心,广东佛山528000

出　　处：《中国性科学》2020年第5期39-43,共5页Chinese Journal of Human Sexuality

摘　　要：目的分析可能影响降调节后激素替代周期冷冻胚胎移植结局的相关因素。方法选取2015年1月至2018年5月佛山市妇幼保健院诊治的150例经降调节后激素替代周期冷冻胚胎移植辅助生殖的患者作为研究对象。仔细阅览患者临床资料,记录其性别、年龄、不孕年限、不孕类型等一般情况,将种植失败者作为非临床妊娠组(n=91),种植成功者作为临床妊娠组(n=59),将可能影响降调节后激素替代周期冷冻胚胎移植结局的相关因素纳入,经χ^2检验与多项Logistic逐步回归分析检验,找出可能的高危因素。结果全部150例患者胚胎移植数量共301个,每个周期移植胚胎(2.01±0.45)个,胚胎着床率为22.92%,获得临床妊娠者59例,临床妊娠率39.33%;经χ^2检验与多项Logistic条件逐步回归分析检验证实,移植当天内膜厚度、胚胎移植数量、优质胚胎数量均可能是影响降调后激素替代周期冷冻胚胎移植结局的危险因素,差异具有统计学意义(P<0.05),且以移植胚胎数量、优质胚胎数量影响较显著。结论降调节后激素替代周期冷冻胚胎移植中,移植胚胎数量越多、优质胚胎数量越多,临床妊娠率越高,同时移植结局还受到子宫内膜厚度的影响,故应根据患者子宫内膜厚度选择合适的移植日,以提高临床妊娠率。Objective To analyze the related factors influencing the outcome of hormone replacement cycle frozen embryo transfer after down-regulation Methods 175 patients who underwent assisted reproduction with hormone replacement cycle frozen embryo transfer after down-regulation from January 2015 to May 2018 in our hospital were selected as subjects.The clinical data of the patients were carefully reviewed,including the gender,age,duration of infertility,and types of infertility.According to the transplantation outcome,the patients were divided into the non-clinical pregnancy group and clinical pregnancy group.The relevant factors that might affect the outcome of hormone replacement cycle frozen embryo transfer after down-regulation were included,and the possible high-risk factors were identified by chi-square test and multiple Logistic stepwise regression analysis.Results The total number of embryo transfer in all the 150 patients was 301;the average number of embryo transfer per cycle was(2.01±0.45);the embryo implantation rate was 22.92%;59 cases were clinically pregnant,the clinical pregnancy rate of 39.33%.The chi-square test and multiple Logistic conditional stepwise regression analysis confirmed that the intimal thickness,the number of embryo transfer,the number of high-quality embryos on the day of transplantation could be the risk factors for the outcome of hormone replacement cycle frozen embryo transfer after down-regulation(OR>1,P<0.05),and the effect of the number of embryo transfer and the number of high-quality embryos were the most significant.Conclusions In the hormone replacement cycle frozen embryo transfer,the more the number of embryo transfer and the number of high-quality embryos,the higher the clinical pregnancy rate.Besides,the outcome of transfer is also affected by the endometrial thickness.Therefore,appropriate transplant days should be selected according to patients′endometrial thickness,so as to improve the clinical pregnancy rate.

关 键 词：降调节 激素替代周期 冷冻胚胎移植 临床妊娠 影响因素 

分 类 号：R714[医药卫生—妇产科学]