孕前2型糖尿病孕妇孕期补充维生素D的围产结局分析  

The perinatal outcomes of pregnant women with type 2 diabetes mellitus taking vitamin D supplement

作　　者：刘海艳[1] 马瑶[1] 李贝[1] 陈磊[1] 贾红梅[1] 王荣 LIU Haiyan;MA Yao;LI Bei;CHEN Lei;JIA Hongmei;WANG Rong(Department of Obstetrics,Haidian Maternal and Child Health Hospital,Beijing 100080,China)

机构地区：[1]北京市海淀区妇幼保健院产科,北京100080

出　　处：《中国性科学》2020年第5期43-45,共3页Chinese Journal of Human Sexuality

摘　　要：目的研究孕前2型糖尿病孕妇孕期补充维生素D的围产结局。方法选取2017年1月至2018年8月在北京市海淀区妇幼保健院产科建档并住院分娩,且在孕前诊断为2型糖尿病的82例孕妇作为研究对象。将其随机分为试验组和对照组,每组41例孕妇。两组孕妇均接受营养科指导饮食;试验组孕妇保证每日总能量摄入的同时,每日口服1000 U维生素D,分2次服用;对照组孕妇每日2次口服安慰剂。口服维生素D或安慰剂的时间从孕13周至孕28周。比较两组孕妇的孕30周空腹血糖、糖化血红蛋白,以及早产、妊娠期高血压疾病、巨大儿等发生率情况。结果试验组孕妇的孕30周糖化血红蛋白明显低于对照组孕妇,其差异具有统计学意义(P<0.05)。试验组孕妇的孕30周Vit D水平明显高于对照组孕妇,其差异具有统计学意义(P<0.05)。试验组孕妇妊娠期高血压疾病发生率和早产发生率均明显少于对照组孕妇,其差异均具有统计学意义(均P<0.05)。试验组孕妇大于胎龄儿发生率明显少于对照组孕妇,其差异具有统计学意义(P<0.05)。结论孕前诊断2型糖尿病孕妇孕期补充维生素D,可以改善围产结局。Objective To study the perinatal outcome of pregnant women with type 2 diabetes mellitus taking vitamin D supplementation.Methods A total of 82 pregnant women with type 2 diabetes mellitus in our hospital from January 2017 to August 2018 were selected and randomly divided into experiment group and control group.The two groups both accepted diet guidance by nutritional department.Women in the experiment group were given 1000 U vitamin D orally twice a day,while women in the control group were given placebo twice a day,both from 13 gestational weeks to 28 gestational weeks.The fasting glucose and glycated hemoglobin in 30 gestational weeks,and the incidences of premature labor,hypertensive disorders complicating pregnancy and macrosomia were compared between the two groups.Results Experiment group had lower glycosylated hemoglobin and higher vitamin D level than control group in 30 gestational weeks,all with statistically significant differences(P<0.05).The incidences of premature labor,hypertensive disorders and large for gestational age in the experiment group were lower than those in the control group accordingly,all with statistically significant differences(P<0.05).Conclusions Supplementation of vitamin D during pregnancy can improve the perinatal outcome of pregnant women with type 2 diabetes.

关 键 词：糖尿病 25-羟维生素D 围产结局 

分 类 号：R714[医药卫生—妇产科学]