子宫内膜异位症伴不孕患者ER-α基因多态性与GnRH-a治疗效果的关系  

Relationship between ER-αgene polymorphism and the treatment effect of GnRH-a on infertility patients with endometriosis

作　　者：李江鹏[1] 王建锋[1] 杨晶洁 马文娟 王恒[1] LI Jiangpeng;WANG Jianfeng;YANG Jingjie;MA Wenjuan;WANG Heng(Department of Obstetrics and Gynecology,Xi′an Fourth Hospital,Xi′an 710000,Shaanxi,China;Department of Geriatrics,Xi′an Center for Mental Health,Xi′an 710000,Shaanxi,China)

机构地区：[1]西安市第四医院妇产科,西安710000 [2]西安市精神卫生中心老年病科,西安710000

出　　处：《中国性科学》2020年第5期88-91,共4页Chinese Journal of Human Sexuality

摘　　要：目的探讨雌激素受体-α(ER-α)基因多态性与子宫内膜异位症合并不孕患者行促性腺激素释放激素激动剂(GnRH-a)治疗效果的关系,明确是否存在与疗效有关的基因型。方法选取2016年3月至2018年3月西安市第四医院妇产科诊治并手术的93例子宫内膜异位症伴不孕患者作为研究对象。进行ER-α基因多态性检测及基因分型,给予患者3个周期GnRH-a治疗,随访12个月比较不同ER-α基因型患者经GnRH-a治疗后妊娠成功率、复发率以及术后痛经评分差异。结果93例患者PvuⅡ-397 T>C多态位点3种基因型分别为:TT型27例(29.0%),TC型29例(31.2%),CC型37例(39.8%);XbaⅠ-351 A>G多态位点基因型分别为AA型18例(19.4%),AG型37例(39.8%),GG型38例(40.8%);PvuⅡ-397 T>C位点TT、TC、CC基因型患者妊娠成功、复发率、术后痛经评分比较,差异均无统计学意义(P>0.05);XbaⅠ-351 A>G位点AA、AG、GG基因型妊娠成功率、复发率、术后痛经评分比较,差异具有统计学意义(P<0.05)。结论ER-α基因XbaⅠ-351 A>G位点基因多态性与术后GnRH-a治疗子宫内膜异位症合并不孕患者疗效有关。Objective To study the relationship between the estrogen receptor alpha(ER-α)gene polymorphism and the treatment effect of gonadotropin-releasing hormone agonist(GnRH-a)treatment on infertility patients with endometriosis,in order to identify the genotype related to the curative effect.Methods 93 infertility patients with endometriosis treated in Xi′an Fourth Hospital from March 2016 to March 2018 were selected.ER-αgene polymorphism detection and genetic classification was performed.All the patients received three GnRH-a treatment cycles and were followed up for 12 months to compare the pregnancy success rate,recurrence rate and postoperative pain scores after treatment between patients with different ER-αgenotypes.Results Among the 93 patients,three genotypes of PvuⅡ-397-T>C polymorphism loci were TT type(27 cases,29.0%),TC type(29 cases,31.2%)and CC type(37 cases,39.8%);three genotypes of XbaI-351 A>G polymorphism loci were AA type(18 cases,19.4%),AG type(37 cases,39.8%)and GG type(38 cases,40.8%).There was no statistically significant differences in the pregnancy success rate,recurrence rate and postoperative pain scores between the TT type,TC type and CC type in the genotypes of PvuⅡ-397-T>C polymorphism loci(P>0.05);There were statistically significant differences in the pregnancy success rate,recurrence rate and postoperative pain scores between the AA type,AG type and GG type in the genotypes of XbaI-351 A>G polymorphism loci(P<0.05).Conclusions ER-αgene loci XbaI-351 A>G gene polymorphism is correlated with the postoperative treatment effect of GnRH-a on infertility patients with endometriosis.

关 键 词：子宫内膜异位症伴不孕 雌激素受体-Α 基因多态性 促性腺激素释放激素激动剂 

分 类 号：R711[医药卫生—妇产科学]