10126例儿童血清食物特异性IgG检测分析  

Detection and analysis of serum food-specific IgG in 10126 children

作　　者：侯丽英 HOU Liying(Department of Clinical Laboratory,Tianjin Children′s Hospital,Tianjin 300400,China)

机构地区：[1]天津市儿童医院检验科,天津300400

出　　处：《检验医学与临床》2020年第12期1708-1711,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨天津地区儿童常见食物不耐受情况,为临床诊断儿童过敏性疾病提供理论依据。方法采用免疫印迹法检测10126例儿童血清中食物特异性IgG抗体水平,分析常见食物不耐受阳性率与性别、年龄、季节之间的关系。结果10126例患儿中有9332例血清食物特异性IgG抗体阳性,阳性率为92.2%。阳性率较高的前3位依次是鸡蛋(74.2%)、牛奶(68.1%)和小麦(55.0%)。其中仅对1种食物不耐受患儿为1260例(12.4%),对2种食物不耐受患儿为1537例(15.2%),对2种以上食物不耐受患儿例数呈下降趋势。不同年龄段患儿血清食物特异性IgG抗体总体阳性率比较,差异有统计学意义(P<0.05)。14种食物不耐受阳性率在4个年龄组之间的差异均有统计学意义(P<0.05)。不同性别间食物特异性IgG抗体总体阳性率差异无统计学意义(P>0.05),男童对牛奶和蘑菇不耐受阳性率略高于女童,差异有统计学意义(P<0.05)。不同季节患儿血清食物特异性IgG抗体总体阳性率差异有统计学意义(P<0.05)。结论鸡蛋、牛奶和小麦是天津地区导致儿童食物不耐受的主要过敏原。血清食物特异性IgG抗体检测对儿童食物不耐受的预防和诊断有一定的应用价值。Objective To explore the common food intolerance of children in Tianjin area and to provide a theoretical basis for clinical diagnosis of allergic diseases in children.Methods The levels of food-specific IgG antibodies in 10126 children′s sera were detected by immunoblotting,and the relationship between common food intolerance positive rates and gender,age and season was analyzed.Results Among 10126 patients,9332 cases were positive for serum food-specific IgG antibodies,and the positive detection rate was 92.2%.The top three positive rates were followed by eggs(74.2%),milk(68.1%)and wheat(55.0%).Among them,1260 cases(12.4%)were intolerant to one kinds of food,1537 cases(15.2%)were intolerant to two kinds of food,and the number of children who were intolerant to two or more kind of food showed a downward trend.The overall positive rate of serum food-specific IgG antibody in children of different ages was statistically significant(P<0.05).The specific analysis of 14 food intolerance positive rates was statistically significant among the four age groups(P<0.05).There was no significant difference in the overall positive rate of food-specific IgG antibody between different sexes(P>0.05).The positive rate of milk and mushroom in boys was slightly higher than those in girls,the difference was statistically significant(P<0.05).The positive rate of serum food-specific IgG antibody of children in different seasons was statistically significant(P<0.05).Conclusion Eggs,milk and wheat are the major allergens in the Tianjin area that cause food intolerance in children.Serum food-specific IgG antibody detection has certain application value in the prevention and diagnosis of food intolerance in children.

关 键 词：食物不耐受 特异性IGG抗体 儿童 过敏原 天津 

分 类 号：R446.6[医药卫生—诊断学]