盐酸特拉唑嗪片联合氯沙坦钾对高血压患者的治疗效果及对氧化应激反应的影响  

Therapeutic effect of terazosin hydrochloride tablets combined with losartan potassium on hypertensive and oxidative stress

作　　者：刘亚南 胡莹莹 张海燕 朱凤娟 Liu Yanan;Hu Yingying;Zhang Haiyan;Zhu Fengjuan(Department of Pharmacy,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China)

机构地区：[1]中国中医科学院望京医院药学部,北京100102

出　　处：《中国医药》2020年第6期859-863,共5页China Medicine

摘　　要：目的探究盐酸特拉唑嗪片联合氯沙坦钾对高血压患者的治疗效果及对氧化应激反应的影响。方法选取2018年4月至2019年4月于中国中医科学院望京医院接受治疗高血压患者108例,按照随机数字表法分为氯沙坦钾组、联合治疗组各54例,氯沙坦钾组患者使用氯沙坦钾进行治疗,联合治疗组患者使用盐酸特拉唑嗪片联合氯沙坦钾进行治疗。比较2组患者治疗前后血压及24 h血压变异性、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)、肌酸激酶水平、血清一氧化氮、血管紧张素Ⅱ(AngⅡ)、可溶性细胞间黏附分子1(SICAM-1)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化脂、丙二醛水平,对比2组患者的疗效及不良反应发生情况。结果治疗后联合治疗组患者收缩压、舒张压、24 h舒张压变异性、24 h收缩压变异性水平均低于氯沙坦钾组(均P<0.05)。治疗后联合治疗组血清乳酸脱氢酶、CK-MB、肌酸激酶、AngⅡ、SICAM-1、过氧化脂、丙二醛水平低于,一氧化氮、GSH-Px水平高于氯沙坦钾组(均P<0.05)。氯沙坦钾组显效25例、有效17例、无效12例,联合治疗组显效31例、有效19例、无效4例,联合治疗组总有效率高于氯沙坦钾组[92.6%(50/54)比77.8%(42/54)],差异有统计学意义(χ2=4.696,P=0.030)。氯沙坦钾组心悸1例、腹痛2例、恶心2例,不良反应发生率9.3%(5/54),联合治疗组心悸3例、腹痛3例、恶心2例,不良反应发生率14.8%(8/54),2组不良反应发生率差异无统计学意义(χ2=0.787,P=0.375)。结论盐酸特拉唑嗪片联合氯沙坦钾对高血压患者进行治疗,能够改善患者血压、血压变异性指标水平,减轻患者心肌损伤严重程度,改善患者血管内皮功能,提升患者抗氧化能力,治疗效果显著。Objective To explore the therapeutic effect of terazosin hydrochloride tablets combined with losartan potassium on hypertensive and oxidative stress response.Methods Totally 108 patients with hypertension in Wangjing Hospital,China Academy of Chinese Medical Sciencesfrom April 2018 to April 2019 were randomly divided into losartan potassium group and combined treatment group,with 54 cases in each group.Losartan potassium group was treated with losartan potassium;combined treatment group was treated with terazosin hydrochloride tablets and losartan potassium.The blood pressure and blood pressure variability were measured in two groups.The levels of lactate dehydrogenase(LDH),creatine kinase isoenzyme(CK-MB)and creatine kinase(CK)were measured by enzyme-linked immunosorbent assay(ELISA).The levels of serum nitric oxide(NO),angiotensinⅡ(AngⅡ),soluble intercellular adhesion molecule-1(SICAM-1)were measured by immunotransmittance turbidimetry.The levels of glutathione peroxidase(GSH-Px),lipid peroxide(LPO)and malondialdehyde(MDA)were detected;the therapeutic effects and adverse reactions were compared between the two groups.Results After treatment,the systolic blood pressure,diastolic blood pressure,24 h diastolic blood pressure variability(DBPV),24 h systolic blood pressure variability(SBPV)levels in the combined treatment group were lower than those in losartan potassium group(P<0.05).The levels of LDH,CK-MB,CK,AngⅡ,SICAM-1,LPO and MDA in the combined treatment group were lower than those in losartan potassium group(P<0.05).After treatment,the levels of NO and GSH-Px in the combined treatment group were higher than those in the losartan potassium group(P<0.05).The total effective rate of combined treatment group was higher than that of losartan potassium group(P<0.05).The incidence of adverse reactions in the combined treatment group was slightly higher than that in the losartan potassium group but there was no significant difference(P>0.05).Conclusion The use of terazosin hydrochloride tablets combined with l

关 键 词：高血压 盐酸特拉唑嗪片 氯沙坦钾 氧化应激 

分 类 号：R544.1[医药卫生—心血管疾病]