甲氨蝶呤皮下注射治疗应用与展望  

Subcutaneous injection of methotrexate: therapeutic application and future prospects

作　　者：刘海波[1] 孔庆涛[1] 桑红[1] Liu Haibo;Kong Qingtao;Sang Hong(Department of Dermatology,General Hospital of Eastern Theater Command(previously named as Nanjing General Hospital of Nanjing Military Command),Nanjing 210002,China)

机构地区：[1]东部战区总医院(原南京军区南京总医院)皮肤科,南京210002

出　　处：《中华皮肤科杂志》2020年第6期483-486,共4页Chinese Journal of Dermatology

基　　金：江苏省皮肤病学创新团队项目(CXTDA2017038);中国博士后科学基金资助项目(2015T81134)。

摘　　要：研究表明,甲氨蝶呤皮下注射较口服途径可以获得更快、更好的吸收和更高的血药浓度以及较低的生物利用度变异度。在类风湿关节炎患者和银屑病患者,甲氨蝶呤皮下注射的疗效显著优于口服途径,并且胃肠道不良反应发生率更低。对于甲氨蝶呤口服疗效欠佳或者不耐受的患者,改为皮下注射后仍然可以获得较好的治疗反应。甲氨蝶呤皮下注射可以作为生物制剂使用前的治疗选择,可节省大量费用。总之,甲氨蝶呤皮下注射具有较好的临床应用前景。Current evidence shows that subcutaneous injection of methotrexate results in more rapid and better absorption,higher blood drug levels and less variable exposure than oral dosing.Among patients with rheumatoid arthritis or psoriasis,subcutaneous methotrexate is more effective than oral methotrexate,and has a lower risk of gastrointestinal complaints.For patients in whom oral methotrexate is proved to be inadequate or intolerant,subcutaneous methotrexate also shows good efficacy.Subcutaneous methotrexate can serve as a treatment option before the use of biological agents,and in this way,large amounts of money can be saved.Subcutaneous methotrexate has good application prospects for clinical practice.

关 键 词：甲氨蝶呤 注射 皮下 银屑病 风湿性疾病 

分 类 号：R977[医药卫生—药品]