成人血清铁蛋白与代谢综合征之间的关联性分析  

Relationship between serum ferritin levels and metabolic syndrome in adults

作　　者：王树英[1] 高铭 顾叶青[2] 杨慧君 孟革[2] 张卿[3] 刘莉[3] 宋崑[3] 牛凯军[2,3] Wang Shuying;Gao Ming;Gu Yeqing;Yang Huijun;Meng Ge;Zhang Qing;Liu Li;Song Kun;Niu Kaijun(Dapartment of ICU2,Tianjin 4th Centre Hospital,Tianjin 300140,China;Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,China;Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津市第四中心医院ICU2科,300140 [2]天津医科大学营养流行病学研究所、公共卫生学院,300070 [3]天津医科大学总医院健康管理中心,300052

出　　处：《中华内分泌代谢杂志》2020年第5期393-399,共7页Chinese Journal of Endocrinology and Metabolism

基　　金：天津市科技支撑计划重点项目(11ZCGYSY05700、12ZCZDSY20400、13ZCZDSY20200)。

摘　　要：目的探究血清铁蛋白五分位水平与代谢综合征(MS)在不同性别成年人群之间的关联性。方法研究人群为TCLSIH队列于2007至2015年期间收集的19563例18岁及以上研究对象。血清铁蛋白浓度采用酶联免疫法测定,MS根据中华医学会糖尿病学分会2013年制定的MS诊断标准予以诊断。采用多元logistic回归分析评估血清铁蛋白五分位水平与MS患病率在不同性别之间的关联。结果在调整混杂因素后,MS患病率随着血清铁蛋白水平的升高而逐渐升高,在男性及女性中观察到类似的结果。将不同性别研究对象按照血清铁蛋白水平分别分为5个亚组,以水平1组为对照,logistic回归显示,按男性及女性的血清铁蛋白五分位水平从低到高,MS患病率的比值比(95%置信区间)分别为1.142(0.998,1.307),1.382(1.210,1.579),1.680(1.472,1.917),2.085(1.827,2.380;趋势性P<0.01)和1.147(0.911,1.444),1.346(1.075,1.687),1.567(1.268,1.941),2.444(1.981,3.023;趋势性P<0.01)。结论在不同性别成年人群中,血清铁蛋白水平与代谢综合征正相关。Objective To access the independent associations between serum ferritin quintile levels and metabolic syndrome(MS)in adults of different genders.Methods 19563 participants over the age of 18 years were recruited from"TCLSIH Cohort Study"from 2007 to 2015.Serum ferritin concentration was measured by Enzyme-linked immunoassay,while metabolic syndrome was diagnosed according to MS diagnostic criteria formulated by Chinese Diabetes Society in 2013.Multiple logistic regression analysis was used to assess the association between serum ferritin quintile levels and the prevalence of MS in males and females.Results After adjusting the confounding factors,the overall prevalence of MS gradually increased with the increasing of serum ferritin levels,similar results were observed in males and females.Subjects were divided into 5 subgroups according to serum ferritin levels.Compared with level 1 group,logistic regression showed that the serum ferritin quintiles of males and females ranged from low to high,the OR(95%confidence interval)for metabolic syndrome were 1.142(0.998,1.307),1.382(1.210,1.579),1.680(1.472,1.917),2.085(1.827,2.380),respectively(Ptrend<0.01),and 1.147(0.911,1.444),1.346(1.075,1.687),1.567(1.268,1.941),2.444(1.981,3.023),respectively(Ptrend<0.01).Conclusion The elevated ferritin levels were positively related to the prevalence of metabolic syndrome in adults of different genders.

关 键 词：血清铁蛋白 代谢综合征 胰岛素抵抗 慢性炎症 横断面研究 

分 类 号：R589[医药卫生—内分泌]