斑蝥酸钠维生素B6联合化疗对肺癌疗效分析  

Analysis of the Efficacy of Sodium Cantharidin And Vitamin B 6 Combined with Chemotherapy on Lung Cancer

作　　者：朱文忠[1] 童舟[1] 徐涛 ZHU Wenzhong;TONG Zhou;XU Tao(Chizhou People′s Hospital of Anhui Province,Chizhou 247000,China)

机构地区：[1]安徽省池州市人民医院,池州247000

出　　处：《世界中医药》2020年第11期1607-1610,共4页World Chinese Medicine

基　　金：安徽省自然科学基金项目(1608085QH214)。

摘　　要：目的:观察化疗联合斑蝥酸钠维生素B6治疗肺癌的效果。方法:选取2017年1月至2019年10月池州市人民医院收治的晚期肺腺癌患者66例作为研究对象,按照用药方法不同分为对照组与观察组,每组33例,对照组通过顺铂联合培美曲塞二钠方案化疗治疗,观察组在此基础上联合斑蝥酸钠维生素B6治疗,比较2组治疗效果,以及用药前后生命质量评分(FACT-L)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CA21-1)等改变以及药物不良反应。结果:与对照组比较,观察组的近期治疗效果更优(P<0.05);治疗后观察组生命质量评分明显高于对照组(P<0.05);2组CEA、NSE、CA21-1等水平比较差异有统计学意义(P<0.05);观察组不良反应发生率明显低于对照组(P<0.05)。结论:以化疗联合斑蝥酸钠维生素B6治疗能够使肺癌患者的生命质量明显提升,降低不良反应发生率,使肺癌标志性指标明显改善,对延长患者的生存时间有积极意义。Objective:To analyze the effects of chemotherapy combined with sodium cantharidin and vitamin B 6 in patients with lung cancer.Methods:A total of 66 patients with advanced lung adenocarcinoma treated in Chizhou People′s Hospital from January 2017 to October 2019 were selected as the research objects.They were divided into a control group and an experimental group,wit 33 cases in each group.The control group was treated with cisplatin combined with pemetrexed disodium;the experimental group was treated with sodium cantharidin and vitamin B 6 based on the control group.Changes in the treatment effects,quality of life score(FACT-L),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE),cytokeratin 19 fragment(CA21-1),and drug side effects before and after treatment were compared.Results:Compared with the control group,the short-term treatment effects were better in the experimental group(P<0.05);the quality of life score of the experimental group was significantly higher than that of the control group(P<0.05);In the experimental and control groups,CEA,NSE,and CA21-1 levels were significant(P<0.05);the incidence of side effects in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion:The treatment of lung cancer patients with chemotherapy combined with sodium cantharidin and vitamin B 6 can significantly improve the quality of life of patients,reduce the incidence of toxic and side effects,and significantly improve the landmark indicators of lung cancer,which has a positive significance for prolonging the survival time of patients.

关 键 词：肺癌 培美曲塞二钠 顺铂 斑蝥酸钠维生素B6 治疗效果 

分 类 号：R285.6[医药卫生—中药学]