大剂量输血患者去白细胞输血和常规输血的效果观察  

Effect of Leukocyte Removal and Routine Blood Transfusion in Patients with High-dose Blood Transfusion

作　　者：王丽 杨晓伟[2] WANG Li;YANG Xiaowei(Jiamusi Central Blood Station,Jiamusi 154007,China;不详)

机构地区：[1]黑龙江省佳木斯市中心血站,黑龙江佳木斯154007 [2]黑龙江省佳木斯市中心医院

出　　处：《中国医学创新》2020年第17期152-155,共4页Medical Innovation of China

摘　　要：目的:探讨大剂量输血患者去白细胞输血和常规输血的效果。方法:选取2016年7月-2019年7月在佳木斯市中心医院需大剂量输血患者76例,按随机数字表法分为研究组和对照组,每组38例。研究组进行去白细胞输血,对照组进行常规输血。比较两组细胞免疫、体液免疫情况及不良反应发生情况。结果:输血后,研究组CD4^+与CD4^+/CD8^+水平均高于对照组(P<0.05);输血后,两组CD8^+水平比较,差异无统计学意义(P>0.05)。研究组输血前后CD4^+、CD8^+及CD4^+/CD8^+水平,差异均无统计学意义(P>0.05)。对照组输血后CD4^+与CD4^+/CD8^+水平均低于输血前(P<0.05)。对照组输血前后CD8^+水平比较,差异无统计学意义(P>0.05)。输血后,研究组IgA、IgE、IgG与IgM水平均高于对照组(P<0.05)。研究组输血前后IgA、IgE、IgG及IgM水平比较,差异均无统计学意义(P>0.05)。对照组输血后IgA、IgE、IgG及IgM水平均低于输血前(P<0.05)。研究组不良反应发生率低于对照组(P<0.05)。结论:对大剂量输血患者采用去白细胞输血,可使患者细胞与体液免疫情况更加稳定,降低不良反应,值得临床应用。Objective:To investigate the effects of leukocyte removal and routine blood transfusion in patients with high-dose transfusion.Method:A total of 76 patients requiring high-dose transfusion in Jiamusi Central Hospital from July 2016 to July 2019 were selected.They were divided into study group and control group according to the random number table method,with 38 cases in each group.The study group treated with leukocyte removal transfusion,while the control group treated with routine transfusion.Cellular immunity,humoral immunity and adverse reactions were compared between the two groups.Result:After transfusion,CD^4+and CD^4+/CD^8+levels in the study group were higher than those in the control group(P<0.05).After transfusion,there was no significant difference in CD^8+between the two groups(P>0.05).There were no significant differences in CD^4+,CD^8+and CD^4+/CD^8+levels before and after transfusion in the study group(P>0.05).The levels of CD^4+and CD^4+/CD^8+in the control group after transfusion were lower than those before transfusion(P<0.05).There was no significant difference in CD^8+level of the control group before and after transfusion(P>0.05).After transfusion,the levels of IgA,IgE,IgG and IgM in the study group were higher than those in the control group(P<0.05).There were no significant differences in the levels of IgA,IgE,IgG and IgM before and after transfusion in the study group(P>0.05).The levels of IgA,IgE,IgG and IgM in the control group after transfusion were lower than those before transfusion(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion:The use of leukocyte removal transfusion in patients with high-doses transfusion can make the cellular and humoral immunity of patients more stable and reduce adverse reactions,which is worthy of clinical application.

关 键 词：大剂量输血 去除白细胞 免疫功能 

分 类 号：R457.1[医药卫生—治疗学]