D-D及FIB在危重症新生儿早期DIC诊断中的检测意义研究  

Detection Significance of D-D and FIB in the Diagnosis of Critically Ill Neonates with Early DIC

作　　者：张远朝[1] 冯荣波 ZHANG Yuanchao;FENG Rongbo(Xinyi People’s Hospital,Xinyi 525300,China)

机构地区：[1]广东省信宜市人民医院,广东信宜525300

出　　处：《中国医学创新》2020年第18期106-109,共4页Medical Innovation of China

基　　金：茂名市科技计划项目(2019007)。

摘　　要：目的:探究D-二聚体(D-D)及纤维蛋白原(FIB)在危重症新生儿早期DIC诊断的检测意义.方法:选取2018年1月-2020年1月本院收治的50例早期DIC危重症新生儿为观察组,另选取同时期的30例健康新生儿为对照组.比较两组入院时D-D及FIB的检测结果,比较观察组入院时及治疗后的D-D及FIB的检测结果,并比较观察组中不同疗效者入院时D-D及FIB的检测结果.结果:观察组入院时D-D水平明显高于对照组,而FIB水平低于对照组(P<0.05).观察组治疗后D-D水平低于入院时,而FIB水平高于入院时(P<0.05).观察组治疗显效者入院时D-D水平低于治疗有效与无效者,且治疗有效者低于无效者(P<0.05).观察组治疗显效者入院时FIB水平均高于治疗有效与无效者,且治疗有效者高于无效者(P<0.05).结论:危重症新生儿早期DIC患儿的D-D水平升高,而FIB降低,D-D及FIB的检测有助于早期DIC的诊断,检测意义较高.Objective:To explore the detection significance of D-Dimer(D-D)and fibrinogen(FIB)in the diagnosis of critically ill neonates with early DIC.Method:A total of 60 critically ill neonates with early DIC from January 2018 to January 2020 were selected as the observation group,and another 30 healthy neonates in the same period were selected as the control group.The detection results of D-D and FIB at admission were compared between the two groups.The detection results of D-D and FIB of the observation group at admission and after treatment were compared.The detection results of D-D and FIB at admission of patients with different curative effects in the observation group were compared.Result:The D-D level of the observation group at admission was significantly higher than that of the control group,while the FIB level was lower than that of the control group(P<0.05).The D-D level in the observation group after treatment was lower than that at admission,while the FIB level was higher than that at admission(P<0.05).The D-D level at admission of the patients with obvious therapeutic effect in the observation group was lower than that of the patients with effective and ineffective treatment,and the D-D level of the patients with effective treatment was lower than that of the patients with ineffective treatment(P<0.05).The FIB level of the patients with obvious therapeutic effect in the observation group was higher than that in the patients with effective and ineffective treatment,and the FIB level of effective treatment was higher than that in the patients with ineffective treatment(P<0.05).Conclusion:The D-D level of critically ill neonates with early DIC is increased,while the FIB level is decreased,the detection of D-D and FIB was helpful to the diagnosis of early DIC,and the detection significance is high.

关 键 词：D-D FIB 危重症新生儿 早期DIC 

分 类 号：R722.1[医药卫生—儿科]