The 3D organization of genome in the nucleus: from the nucleosome to the 4D nucleome  

作　　者：Guohong Li 

机构地区：[1]National Laboratory of Bio-macromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Science China(Life Sciences)》2020年第6期791-794,共4页中国科学（生命科学英文版）

摘　　要：The genetic information,stored in the linear sequences of DNA,encodes all of the genes that a living organism uses to produce proteins and RNAs essential for various cellular functions.In eukaryotes,however,genomic DNA is hierarchically and efficiently packaged into multiple-level chromatin structures within the nucleus,including the nucleosome,30 nm fibers,chromatin loops,topology associated domains(TADs).

关 键 词：The 3D organization of genome in the nucleus from the nucleosome to the 4D nucleome 

分 类 号：Q75[生物学—分子生物学]