Roles of insulin-like growth factor Ⅱ in regulating female reproductive physiology  

作　　者：Tahir Muhammad Mengjing Li Jianfeng Wang Tao Huang Shigang Zhao Han Zhao Hongbin Liu Zi-Jiang Chen 

机构地区：[1]Center for Reproductive Medicine,Cheeloo College of Medicine,Shandong University,Jinan 250012,China [2]National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Shandong University,Jinan 250012,China [3]Key laboratory of Reproductive Endocrinology of Ministry of Education,Shandong University,Jinan 250012,China [4]Shandong Provincial Clinical Medicine Research Center for Reproductive Health,Shandong University,Jinan 250012,China [5]Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics,Shanghai 20000,China [6]Center for Reproductive Medicine,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200000 China

出　　处：《Science China(Life Sciences)》2020年第6期849-865,共17页中国科学（生命科学英文版）

基　　金：the National Key Research and Development Program of China (2017YFC1001500 and 2016YFC1000600);the Scientific Innovation Program of Shenzhen City, China, under basic research program (JCYJ20180305163835455);the Young Scholars Program of Shandong University (2016WLJH50);the Natural Science Foundation of Shandong Province (ZR2017MH049)。

摘　　要：The number of growth factors involved in female fertility has been extensively studied, but reluctance to add essential growth factors in culture media has limited progress in optimizing embryonic growth and implantation outcomes, a situation that has ultimately led to reduced pregnancy outcomes. Insulin-like growth factor Ⅱ(IGF-Ⅱ) is the most intricately regulated of all known reproduction-related growth factors characterized to date, and is perhaps the predominant growth factor in human ovarian follicles. This review aims to concisely summarize what is known about the role of IGF-Ⅱ in follicular development, oocyte maturation, embryonic development, implantation success, placentation, fetal growth, and in reducing placental cell apoptosis, as well as present strategies that use growth factors in culture systems to improve the developmental potential of oocytes and embryos in different species. Synthesizing the present knowledge about the physiological roles of IGF-Ⅱ in follicular development, oocyte maturation, and early embryonic development should, on the one hand, deepen our overall understanding of the potential beneficial effects of growth factors in female reproduction and on the other hand support development(optimization) of improved outcomes for assisted reproductive technologies.

关 键 词：growth factors IGF-Ⅱ oocyte maturation embryonic development PLACENTATION fetal growth 

分 类 号：R339.22[医药卫生—人体生理学]