植物雌激素非基因组效应研究的现状与将来  

Current status and future of non-genomic effects of phytoestrogens

作　　者：杨鑫月 刘海鑫 贺爽[1,2] 邵瑞[1,2] 冯宇新 朱彦[1,2] YANG Xin-yue;LIU Hai-xin;HE Shuang;SHAO Rui;FENG Yu-xin;ZHU Yan(Tianjin Modern Chinese Medicine Key Laboratory,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Tianjin International Biomedical Research Institute,Chinese Medicine New Drug Research and Development Center,Tianjin 300457,China;Shanxi University of Traditional Chinese Medicine,Taiyuan 030619,China)

机构地区：[1]天津中医药大学,天津市现代中药重点实验室,天津300193 [2]天津国际生物医药联合研究院中药新药研发中心,天津300457 [3]山西中医药大学,山西太原030619

出　　处：《药学学报》2020年第5期854-860,共7页Acta Pharmaceutica Sinica

基　　金：国家重点研发计划项目(2018YFC1704502);国家科技重大专项(2018ZX01031301);国家自然科学基金资助项目(81873037).

摘　　要：植物雌激素具有类雌激素效应,其药理作用体现在防治骨质疏松、心血管疾病和肿瘤等方面,但具体机制尚不明确。近年来,雌激素受体α介导的快速非基因组效应已被确定在雌激素相关疾病发病机制中起着重要作用。植物雌激素通过非基因组效应发挥药理作用的机制研究也越来越受到关注。本文总结了雌激素受体α介导的非基因组效应的研究进展,分析了快速非基因组效应介导某些植物雌激素药理作用的可能,并展望了植物雌激素在雌激素受体α介导的非基因组效应研究领域中的发展前景。Phytoestrogens exhibit various pharmacological estrogen-like effects, such as in the prevention and treatment of osteoporosis, cardiovascular diseases, tumors, etc., but the specific mechanism is still unclear. In recent years, estrogen receptor alpha-mediated rapid non-genomic effects have been identified to play an important role in the pathogenesis of estrogen-related diseases. The research of phytoestrogens exerting pharmacological effects through non-genomic effects has also received increasing attention. This article summarizes the research progress in estrogen receptor alpha-mediated non-genomic effects and analyzes the possible involvement of rapid non-genomic effects in certain pharmacological effects of phytoestrogens. The future prospects of estrogen receptor-mediated non-genomic effects by phytoestrogens are also discussed.

关 键 词：植物雌激素 雌二醇 非基因组效应 雌激素受体Α 

分 类 号：R285[医药卫生—中药学]