妇女孕前年龄、谷丙转氨酶及血糖水平与早产关系的队列研究  

Cohort study on the relationship between women′s pre-pregnancy age,alanine aminotransferase,blood glucose level and premature birth

作　　者：庾静云 何伟超 刘建新[1] 陈锦国[1] 姜碧 YU Jingyun;HE Weichao;LIU Jianxin;CHEN Jinguo;JIANG Bi(Dongguan Maternal and Child Health Hospital of Guangdong Province,Dongguan,Guangdong 523000,China)

机构地区：[1]广东省东莞市妇幼保健院,广东东莞523000

出　　处：《公共卫生与预防医学》2020年第3期108-111,共4页Journal of Public Health and Preventive Medicine

基　　金：国家科技基础性工作专项重点项目(2013FY110500);东莞市社会科技发展项目(201950715007842)。

摘　　要：目的探讨妇女孕前年龄、谷丙转氨酶(alanine aminotransferase,ALT)及血糖(blood glucose,GLU)水平对早产的影响。方法基于东莞市免费婚前健康检查和孕前优生健康检查项目,获取受检对象检查结果,追踪随访获取其妊娠结局情况。采用Logistic回归探讨妇女孕前年龄、ALT及GLU水平与早产发生率的关系。结果共有18150名对象参与,发现早产儿1099名,早产率为6.06%。多因素Logistic回归模型分析发现,妇女孕前年龄30~34岁(RR=1.26,95%CI:1.07~1.48)、孕前年龄>34岁(RR=1.82,95%CI:1.52~2.18)、ALT≥40 U/L(RR=1.40,95%CI:1.09~1.80)和GLU>6.1mmol/L(RR=1.74,95%CI:1.01~2.97)为早产的影响因素。结论妇女年龄偏大、谷丙转氨酶异常及高血糖对早产的发生有影响,对孕前开展优生优育健康教育具有重大的指导意义。Objective To investigate the effect of pre-pregnancy age,alanine aminotransferase(ALT),blood glucose(GLU)level on premature birth.Methods Based on the free pre-marital health check-ups and pre-pregnancy eugenic health check-ups in Dongguan,the examination results of the subjects were obtained and the pregnancy outcomes were followed up.Logistic regression models were used to analyze the relationship between women′s pre-pregnancy age,ALT,and GLU levels and the incidence of premature birth.Results A total of 18150 subjects were included in this study,and the overall incidence of premature birth was 6.06%(1099/18150).The women′s pre-pregnancy age 30 to 34(RR=1.26,95%CI:1.07~1.48),age>34(RR=1.82,95%CI:1.52~2.18),ALT≥40 U/L(RR=1.40,95%CI:1.09~1.80)and GLU>6.1 mmol/L(RR=1.74,95%CI:1.01~2.97)were the influencing factors of premature birth.Conclusion Older women,abnormal serum alanine aminotransferase level and hyperglycemia had an impact on the occurrence of premature birth,which has important guiding significance for health education of eugenics before pregnancy.

关 键 词：谷丙转氨酶 血糖 早产 队列研究 

分 类 号：R173[医药卫生—妇幼卫生保健]