不同时段服用柴胡加龙骨牡蛎汤治疗失眠的效果对比  

Comparison of the effects of Chaihu plus the Longgu Muli decoction on insomnia at different periods

作　　者：谢汪传 何燕飞[1] Xie Wangzhuan

机构地区：[1]肇庆市第三人民医院,广东肇庆526060

出　　处：《中医临床研究》2020年第13期107-109,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨不同时段服用柴胡加龙骨牡蛎汤的临床疗效。方法:选取我院2016年1月-2018年12月失眠患者340例,随机分为3组,每组均口服柴胡加龙骨牡蛎汤;其中A组105例(上午九时服药),B组120例(下午三时服药),C组115例(晚上九时服药)。观察三组患者临床疗效、主要症状积分、睡眠时间相关指标和相关激素水平变化情况。结果:比较其余两组,C组的临床疗效明显升高(P <0.05);失眠、烦躁易怒、头痛、胸痛症状积分明显降低(P <0.05);睡眠潜伏期和觉醒时间明显缩短(P <0.05),总睡眠时间明显延长(P <0.05);生长激素(Growth Hormone,GH)、雌激素(E2)明显升高(P <0.05),皮质醇(Cortisol, COR)明显降低(P <0.05)。结论:与其他时段服药比较,失眠患者晚九时服用柴胡加龙骨牡蛎汤,其临床症状和相关激素水平改善更为明显,临床效果更佳。Objective:To explore the clinical effect of Chaihu plus the Longgu Muli decoction(柴胡加龙骨牡蛎汤)at different time.Methods:A total of 340 patients with insomnia from January 2016 to December 2018 in our hospital were randomly divided into 3 groups,and each group was orally administered with Chaihu and Longgu Muli decoction.There were 105 patients in group A(drug taking at 9 am),120 patients in group B(drug taking at 3 pm),and 115 cases in group C(drug taking at 9 pm).Results:Compared with the other two groups,the clinical effect in group C was most increased(P﹤0.05).The scores of insomnia,irritability,headache,and chest pain were most reduced in group C(P﹤0.05).Sleep latency and awakening time were significantly reduced(P﹤0.05),and total sleep time was significantly prolonged in group C(P﹤0.05).Growth hormone and estrogen were most increased in group C(P﹤0.05),and cortisol was most decreased in group C(P﹤0.05).Conclusion:Compared with other times,patients with insomnia who take Chaihu plus the Longgu Muli decoction at 9 pm have more significant improvement in clinical symptoms and related hormone levels,with best clinical effects.

关 键 词：柴胡加龙骨牡蛎汤 失眠 不同时段 临床疗效 

分 类 号：R256.23[医药卫生—中医内科学]