甲巯咪唑片对甲状腺功能亢进的临床效果及对骨代谢指标、转化生长因子-β1及白细胞介素-6水平的影响研究  

Clinical effects of methimazole tablets on hyperthyroidism and on bone metabolism,TGF-β1 and IL-6 levels

作　　者：陈连红 费洪华[2] 王文兰 王斐[3] 马得原 Chen Lianhong

机构地区：[1]青岛大学医学部,山东青岛266555 [2]日照市人民医院,山东日照276800 [3]青岛大学附属医院,山东青岛266555 [4]兰州大学第二临床医学院,甘肃兰州730000

出　　处：《中医临床研究》2020年第13期129-131,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨甲巯咪唑片治疗甲状腺功能亢进的效果。方法:选取我院2016年1月-2018年1月收治的96例甲状腺功能亢进症患者,根据不同治疗分为两组,对照组(48例)接受丙硫氧嘧啶片治疗,观察组(48例)接受甲巯咪唑片治疗,对比两组患者临床疗效和治疗前后血清骨代谢指标[甲状旁腺素(Parathyroid Hormone,PTH)、骨钙素(Bone Glaprotein,BGP)、血清降钙素(Calcitonin,CT)]以及转化生长因子(Transforming Growth Factor,TGF)-β1、白细胞介素(Interlenkin,IL)-6水平。结果:两组患者临床疗效对比差异明显(P<0.05)。治疗前两组患者PTH、BGP、CT水平对比无显著差异(P>0.05);治疗后两组患者PTH水平均显著提高,BGP、CT水平均明显降低,观察组改善更为明显(P<0.05)。治疗前两组患者TGF-β1、IL-6水平对比无显著差异(P>0.05);治疗后两组患者TGF-β1、IL-6水平均明显降低,观察组改善更为明显(P<0.05)。两组患者均没有出现明显不良反应。结论:甲巯咪唑片治疗甲状腺功能亢进的临床效果满意,对血清骨代谢指标、TGF-β1及IL-6水平具有积极的改善作用,值得临床推广应用。Objective:To investigate the effect of methimazole tablets on hyperthyroidism.Methods:96 patients were divided into two groups according to different treatments.The control group received propylthiouracil tablets and the observation group received methimazole tablets.Results:There was a significant difference in efficacy between groups(P﹤0.05).After treatment,PTH levels in groups were significantly increased,BGP and CT levels were significantly decreased,and the improvement in the observation group were more obvious(P﹤0.05).The levels of TGF-β1 and IL-6 in the two groups were decreased,and the improvement in the observation group was more obvious(P﹤0.05).There was no obvious adverse reactions in groups.Conclusion:The clinical effect of methimazole tablets on hyperthyroidism is satisfactory.It shows a positive effect on serum bone metabolism,TGF-β1 and IL-6 levels,is worthy of clinical application.

关 键 词：甲巯咪唑 甲状腺功能亢进 骨代谢指标 转化生长因子-Β1 白细胞介素-6 

分 类 号：R322.5[医药卫生—人体解剖和组织胚胎学]