普通和冻干三七粉的有效成分及药理作用比较  

Comparative evaluation of the active ingredients and pharmacological activities of ordinary P.notoginseng powder and lyophilized P.notoginseng powder

作　　者：张君 孙思勉 赵琳 周航 林冬菊 霍小位 ZHANG Jun;SUN Simian;ZHAO Lin;ZHOU Hang;LIN Dongju;HUO Xiaowei(Key Laboratory of Pharmaceutical Quality Control of Hebei Province,College of Pharmaceutical Science,Hebei University,Baoding 071002,China)

机构地区：[1]河北大学药学院,河北省药物质量分析控制重点实验室,河北保定071002

出　　处：《河北大学学报（自然科学版）》2020年第3期269-275,282,共8页Journal of Hebei University(Natural Science Edition)

基　　金：河北省教育厅资助项目(QN2018153);河北大学大学生创新创业训练计划项目(2018116,2018111);河北大学研究生创新项目(hbu2019ss082)。

摘　　要：为比较普通三七Panax notoginseng粉和冻干三七粉的有效成分及药理活性,通过在显微镜下观察普通三七粉和冻干三七粉的粒径,肉眼观察其混悬液的溶解度,HPLC法检测有效成分含量来明确普通三七粉和冻干三七粉在有效成分方面的区别.通过毛细玻管法、剪尾法、二甲苯所致小鼠耳肿胀实验和器官指数等实验研究普通三七粉和冻干三七粉在药理作用方面的差异.研究结果表明:2种三七粉的粒径、溶解度、有效成分含量存在差异.普通粉高剂量组有一定的凝血作用;冻干粉高剂量组有一定的抗炎作用,2者对免疫器官均无明显影响.To compare the active ingredients and pharmacological activities of ordinary Panax notoginseng powder and freeze-dried P.notoginseng powder.The differences of active ingredients between the ordinary and the freeze-dried P.notoginseng powder were determined by observing the particle size of ordinary powder and freeze-dried P.notoginseng powder under the microscope,visually observing the solubility of the suspension and detecting the active ingredient content by HPLC.The differences of pharmacological effects between ordinary powder and freeze-dried P.notoginseng powder were determined by capillary tube method,tail-cut method,xylene-induced ear swelling test and organ index.The results showed that these two P.notoginseng powders were different in the particle size,solubility and active ingredient content;ordinary powder had strong effect on blood coagulation and lyophilized powder exhibited anti-inflammatory effect;they both had no significant effect on immune organs.

关 键 词：三七 冻干粉 普通粉 有效成分 药理作用 

分 类 号：R96[医药卫生—药理学] R917[医药卫生—药学]