汉族人群中男性勃起功能障碍与色氨酸羟化酶2基因多态性的关系  

Association between erectile dysfunction and polymorphisms of the tryptophan hydroxylase 2 gene in Han population

作　　者：付旭 张贤生[1] Fu Xu;Zhang Xiansheng(Dept of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei 230032)

机构地区：[1]安徽医科大学第一附属医院泌尿外科,合肥230032

出　　处：《安徽医科大学学报》2020年第6期947-950,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81571429)。

摘　　要：目的探讨色氨酸羟化酶2 (TPH2)基因多态性是否与勃起功障碍(ED)是否相关。方法招募59例确诊为ED的男性,另招募151例健康对照者。收集国际勃起功能指数-5 (IIEF-5)和早泄诊断工具(PEDT)的数据。所有ED患者和健康对照组进行TPH2基因多态性的基因测序。统计分析单核苷酸多态性(SNPs)的等位基因频率和基因型频率在患者和对照组间的差异,以及不同遗传模型下的差异分析。结果 rs1007023 G等位基因频率在ED患者中高于对照组,差异有统计学意义(P=0.023)。结论 TPH2基因的SNPs rs1007023在汉族人群中似乎与ED相关。携带rs1007023 G等位基因或G/G+T/G等位基因的男性患ED的可能性较大。Objective To investigate whether the polymorphism of tryptophan hydroxylase 2(TPH2)gene is associated with erectile dysfunction(ED).Methods A total of 59 men diagnosed with ED and 151 healthy controls were recruited.International index of erectile function-5(IIEF-5)and the premature ejaculation diagnostic tool(PEDT)data were collected.All ED patients and healthy controls were genotyped for polymorphisms in the TPH2 gene.Allele and genotype frequencies of single nucleotide polymorphisms(SNPs)were compared between the patients and controls.Result The rs1007023 G allele frequency was significantly higher in ED patients than that in the control group(P=0.023).Conclusion The SNPs rs1007023 of the TPH2 gene seems to be associated with ED in males with the rs1007023 G allele or G/G+T/G allele in the Han population.

关 键 词：男性勃起功能障碍 色氨酸羟化酶2 单核苷酸多态性 

分 类 号：R699[医药卫生—泌尿科学]