A preliminary study on the anti-inflammatory and analgesic effects of two extracts of pine pollen on anoxia and fatigue resistance  

作　　者：Shi-Bo Zhao Suo-Yi Huang Yu-Xin Wei Zhong-Gang Wu Han-Jun Ma Xue-Ying Yu Hui-Man Yang Yi-Jie Wang Yu-Zhu Zeng 

机构地区：[1]College of Clinical Medicine,Youjiang Medical University For Nationalities,Baise 533000,China [2]College of Pharmacy,Youjiang Medical University for Nationalities,Baise 533000,China [3]Key Laboratory of Guangxi's College for the Study of Characteristic Medicine in Youjiang River Basin,Youjiang Medical University for Nationalities,Baise 533000,China [4]College of Basic Medicine,Youjiang Medical University for Nationalities,Baise 533000,China [5]College of Medical Imaging,Youjiang Medical University for Nationalities,Baise 533000,China

出　　处：《TMR Aging》2020年第2期59-66,共8页衰老研究

基　　金：The National Natural Science Foundation of China(No.81360684);Guangxi Key Research and Development Plan Project(Gui Ke AB18221095);China National and Regional University Students Innovation and Entrepreneurship Training Scheme Funding(No.201910599012);High-level Talent Research Projects From Youjiang Medical University For Nationalities(No.01002018079);China National and Autonomous Region Innovation Planning Project for University Students in 2020(2020010599030).

摘　　要：Background:To study the anti-inflammatory,analgesic,fatigue resistant and antihypoxia effects of ethanol extract and water extract of pine pollen.Methods:Two different extracts of pine pollen were prepared into there different concentrations,that is 1.5 mg·mL^-1,4.5 mg·mL^-1 and 7.5 mg·mL^-1 respectively.The extract were studied by xylene-induced ear swelling,acetic acid distortion test and hot plate test.The antihypoxia and antifatigue effects were explored by weight-bearing swimming experiment,routine pressure hypoxia tolerance experiment and liver weight coefficient comparison.Results:Through the study of the four pharmacological effects of ethanol extract and water extract,we found that the anti-inflammatory,analgesic,antithyposia and antifatigue effects of ethanol extract were better than that of water extract.Moreover,the experimental effects significantly improved with the increase of the concentration,and the effect of alcohol increased dose group was accurate(P<0.05).Conclusion:Pine pollen has excellent effects of anti-inflammatory,analgesic,antihypoxia and anti-fatigue.Besides,with the increase of drug concentration,effects tend to be more obvious with positive correlation.

关 键 词：Pine pollen Alcohol extract Water extract Anti-inflammatory effect Analgesic effect ANTIHYPOXIA Fatigue resistance 

分 类 号：R28[医药卫生—中药学]