补铁治疗与学龄前儿童急性呼吸道感染和胃肠炎复发率相关性  

Relationship between Iron Supplementation and Relapse Rates of Acute Respiratory Tract Infection and Gastroenteritis in Preschool Children

作　　者：李丰[1] 赵雁[1] 刘晓风[1] 早木来提古力·吐尔孙 佐日汗·艾萨 Li Feng;Zhao Yan;Liu Xiaofeng(Department of Pediatrics,Second Affiliated Hospital of Xinjiang Medical University,Xinjiang 830063)

机构地区：[1]新疆医科大学第二附属医院小儿儿科,乌鲁木齐830063

出　　处：《医学研究杂志》2020年第6期104-107,共4页Journal of Medical Research

基　　金：新疆少数民族人才特殊培养计划科研项目(201523102);新疆维吾尔自治区卫生厅青年科技人才专项科研项目(2014y02)。

摘　　要：目的探讨补铁治疗在反复呼吸道感染及胃肠炎的疗效。方法选择2017年1~12月期间在笔者医院住院治疗的2~5岁ARTI、GE患儿作为研究对象,同时在门诊体检正常并过去6个月无感染病史儿童作为对照组。检测血红蛋白及血铁蛋白,IDA患儿补铁治疗3个治疗,随访1年观察ARTI、GE复发情况。结果研究组收集118例ARTI、76例GE患儿,对照组收集86例体检儿童。ARTI组85例、GE组52例、对照组29例存在缺铁性贫血。3组Hb水平均低于正常水平,差异无统计学意义;SF均低于正常水平,ARTI组、GE组均低于对照组,差异有统计学意义(P<0.05)。随访3个月后,IDA患儿ARTI组复发率为23.5%,GE组复发率为26.9%,对照组复发率为31.0%;非IDA患儿复发率分别为12.1%、12.5%和8.5%,差异均无统计学意义。补铁治疗3个月后,初始ARTI组复发率下降83.4%,GE组复发率下降83.2%,对照组复发率下降94.2%;继续随访3个月,复发率分别为2.5%、2.6%和2.3%,差异无统计学意义。多重线性回归分析复发相关性,回归模型差异有统计学意义[F(4,280)=25.239,P<0.01],调整R2=0.732。纳入模型的5个自变量中,IDA发生率、SF水平对ARTI或GE复发的相关性差异有统计学意义(P<0.05)。结论ARTI、GE患儿多数存在缺铁性贫血,缺铁的儿童更容易发生复发,一旦铁缺乏得到纠正,儿童ARTI、GE及贫血的复发率可得到长期改善。Objective To study the efficacy of iron supplementation in the treatment of recurrent respiratory tract infection and gastroenteritis.Methods The 2-5 years old children with ARTI and GE who were hospitalized in our hospital from January to December 2017 were selected as the subjects,and the children with normal physical examination in the outpatient department and infected children in the past 6 months were selected as the control group.Hemoglobin and blood ferritin were detected.Three treatments of iron supplementation in children with IDA were followed up for 1 year to observe the recurrence of ARTI and GE.Results In the study group,118 cases of ARTI and 76 cases of GE were collected,and 86 cases of physical examination children were collected in the control group.85 cases in ARTI group,52 cases in GE group and 29 cases in control group had iron deficiency anemia.The level of Hb in the three groups was lower than the normal level,and the difference was not statistically significant.The level of SF in the three groups was lower than the normal level,and the levels in ARTI group and GE group were lower than those in the control group(P<0.05).After 3 months follow-up,the recurrence rates of ARTI group,GE group and control group were 23.5%,26.9%and 31.3%,respectively,while those of non-IDA children were 12.1%,12.5%and 8.5%,respectively.After 3 months of iron supplementation,the recurrence rate decreased by 83.4%in the initial ARTI group,83.2%in the GE group and 94.2%in the control group.After follow-up for 3 months,the recurrence rates were 2.5%,2.6%and 2.3%,respectively.Multiple linear regression analysis showed that the regression model had statistical significance[F(4,280)=25.239,P<0.01].Among the five independent variables included in the model,the prevalence rate of IDA and the level of Hb were significantly correlated with the recurrence of ARTI or GE(P<0.05).Conclusion Most of the children with ARTI and GE have iron deficiency anemia,and children with iron deficiency are more likely to relapse.Once iron defi

关 键 词：学龄前儿童 补铁治疗 急性呼吸道感染 胃肠炎 复发率 

分 类 号：R76[医药卫生—耳鼻咽喉科]