Magnetic Nano-Amorphous-Iron-Oxide-Based Drug Delivery System with Dual Therapeutic Mechanisms  

具有双重治疗机制的磁性纳米无定型氧化铁基药物递送系统

作　　者：Shan Lei Li-an Wang Fu-xing Lin Kun Zeng Mo-zhen Wang Xue-wu Ge 雷珊;王黎安;林福星;曾琨;汪谟贞;葛学武(中国科学院软物质化学重点实验室,中国科学技术大学高分子科学与工程系,合肥230026;三明学院资源与化工学院,三明市氟化工产业技术研究院,三明365004)

机构地区：[1]CAS Key Laboratory of Soft Matter Chemistry,Department of Polymer Science and Engineering,University of Science and Technology of China,Hefei 230026,China [2]College of Resources and Chemical Engineering,Fujian Engineering Research Center for Advanced Fluorine-containing Materials,Sanming University,Sanming 365004,China

出　　处：《Chinese Journal of Chemical Physics》2020年第3期376-384,I0003,共10页化学物理学报（英文）

基　　金：supported by the National Natural Science Foundation of China(No.51473152 and No.51573174);Scientific Research Foundation for Young Talents from Fujian Provincial Department of Education(No.JT180494);Scientific Research Platform Construction Project from Fujian Provincial Department of Science and Technology(No.2018H2002)。

摘　　要：Smart nanoparticles that respond to pathophysiological parameters,such as p H,GSH,and H2O2,have been developed with the huge and urgent demand for the high-efficient drug delivery systems(DDS)for cancer therapy.Herein,cubic poly(ethylene glycol)(PEG)-modified mesoporous amorphous iron oxide(AFe)nanoparticles(AFe-PEG)have been successfully prepared as p H-stimulated drug carriers,which can combine doxorubicin(DOX)with a high loading capacity of 948 mg/g,forming a novel multifunctional AFe-PEG/DOX nanoparticulate DDS.In an acidic microenvironment,the AFe-PEG/DOX nanoparticles will not only release DOX efficiently,but also release Fe ions to catalyze the transformation of H2O2 to·OH,acting as fenton reagents.In vitro experimental results proved that the AFe-PEG/DOX nanoparticles can achieve combination of chemotherapeutic(CTT)and chemodynamic therapeutic(CDT)effects on Hela tumor cells.Furthermore,the intrinsic magnetism of AFePEG/DOX makes its cellular internalization efficiency be improved under an external magnetic field.Therefore,this work develops a new and promising magnetically targeted delivery and dual CTT/CDT therapeutic nano-medicine platform based on amorphous iron oxide.

关 键 词：Cubic amorphous iron oxide nanoparticles p H-responsive CHEMOTHERAPY Chemodynamic therapy Magnetically targeted delivery 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.4[化学工程—制药化工]