Proteasome phase separation: a novel layer of quality control  

作　　者：Victoria Cohen-Kaplan Ido Livneh Aaron Ciechanover 

机构地区：[1]Technion Integrated Cancer Center,The Rappaport Faculty of Medicine and Research Institute,Technion-lsrael Institute of Technology,3109602 Haifa,Israel

出　　处：《Cell Research》2020年第5期374-375,共2页细胞研究（英文版）

摘　　要：Maintenance of the quality control of the cellular proteome involves several pathways and a variety of transient and interchangeable assemblies.A recently discovered membraneless foci that contain一am ong several components—the 26S proteasome complex and that are generated in response to a proteotoxic stress,is the recent addition to this evergrow ing list.One of the fundamental problems in biology is how cells recruit and concentrate their'divisions'of enzymes and reactants in order to respond to different environmental and internal stresses and cues.Eukaryotic cells contain numerous membrane-bound organelles—such as the nucleus,mitochondria,the endoplasmic reticulum and the Golgi apparatus,and lysosomes that carry out specific functions and regulate distinct cellular processes.

关 键 词：SEPARATION apparatus CARRY 

分 类 号：Q24[生物学—细胞生物学]