不同年龄及体质指数对胚胎发育时间动力学参数及胚胎发育潜能的影响  

Effects of different ages and body mass index on embryo development time kinetic parameters and embryo development potential

作　　者：金海霞[1] 王赛赛 宋文妍[1] 姚桂东[1] 石森林[1] 吴瞾婷 刘艳[1] 祁琳 Jin Haixia;Wang Saisai;Song Wenyan;Yao Guidong;Shi Senlin;Wu Zhaoting;Liu Yan;Qi Lin(Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院生殖中心,郑州450052

出　　处：《中华医学杂志》2020年第17期1326-1331,共6页National Medical Journal of China

摘　　要：目的探讨年龄、体质指数(BMI)对胚胎发育时间动力学参数、胚胎发育潜能及临床妊娠结局的影响。方法回顾性分析2016年9月至2018年11月在郑州大学第一附属医院生殖医学中心行体外受精-胚胎移植(IVF-ET)的832例患者共6294枚胚胎的资料,根据年龄分为2组:<35岁组(655例、5076枚胚胎)、≥35岁组(177例、1218枚胚胎);根据BMI分为3组:低体重组(BMI<18.5 kg/m2,47例、355枚胚胎)、正常体重组(18.5~23.9 kg/m2,517例、3813枚胚胎)、超重组(BMI>23.9 kg/m2,268例、2126枚胚胎),比较各组胚胎发育时间动力学参数、胚胎发育潜能及临床妊娠结局。结果<35岁组患者的胚胎发育到3个细胞、4个细胞速度更快;两个年龄组患者囊胚形成率、优质囊胚形成率、妊娠率、种植率、分娩率、活产率、流产率差异均有统计学意义(均P<0.05)。低体重组、正常体重组、超重组患者的正常受精率、卵裂率、胚胎利用率、优质胚胎率、妊娠率、种植率、流产率、分娩率、活产率等差异均无统计学意义(均P>0.05)。结论年龄对部分胚胎发育时间动力学参数有影响,而BMI对其影响较小。Objective To investigate the effects of age and body mass index(BMI)on embryo development time kinetic parameters,embryo development potential and clinical pregnancy outcomes.Methods A retrospective study was conducted to analyze the data of 6294 embryos from 832 patients who underwent in vitro fertilization and embryo transfer(IVF-ET)in the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from September 2016 to November 2018.According to the age,they were divided into two groups:<35-year-old group(655 cases,5076 embryos),≥35-year-old group(177 cases,1218 embryos).According to the BMI,they were divided into three groups:low body mass group(BMI<18.5 kg/m^2,47 cases,355 embryos),normal body recombination(18.5-23.9 kg/m^2,517 cases,3813 embryos),hyperrecombination(BMI>23.9 kg/m^2,268 cases,2126 embryos).Embryo development time kinetic parameters,embryo development potential and clinical pregnancy outcomes in each group were compared.Results Embryo development to 3 cells,4 cells were faster in<35-year-old group than in≥35-year-old group.The blastocyst formation rate,high-quality blastocyst formation rate,pregnancy rate,implantation rate,delivery rate,live birth rate,and abortion rate were all statistically significant(all P<0.05).There were no significant differences in normal fertilization rate,cleavage rate,embryo utilization rate,high quality embryo rate,pregnancy rate,implantation rate,abortion rate,delivery rate,live birth rate between the three BMI groups(all P>0.05).Conclusions The age has an effect on the partial embryo development time kinetic parameters,but BMI has a little effect on it.

关 键 词：年龄 体质指数 胚胎移植 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]