组织工程软骨的研究新进展  

New progresses of tissue engineered cartilage

作　　者：胡坤 陈竹 罗栩伟(综述) 冯刚(审校) HU Kun;CHEN Zhu;LUO Xuwei(reviewing);FENG Gang(checking)(Southwest Medical University School, Lu zhou 646000, Sichuan, China;Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong 637000, Sichuan, China;Precision Medicine Center, Nanchong Central Hospital, Nanchong 637000, Sichuan, China)

机构地区：[1]西南医科大学,四川泸州646000 [2]南充市中心医院·川北医学院第二临床医学院组织工程与干细胞研究所,四川南充637000 [3]南充市中心医院精准医学中心,四川南充637000

出　　处：《西部医学》2020年第6期927-932,共6页Medical Journal of West China

基　　金：四川省教育厅科研项目(18ZB0206);南充市市校合作项目(NSMC20170203,NSMC20170310);南充市应用技术研究与开发资金项目(16YFZJ0024)。

摘　　要：创伤、炎症、退行性变等各种原因导致的软骨损伤是临床上的常见病。由于软骨的自我修复能力极为有限,因此损伤软骨的修复一直是临床上亟待解决的问题。目前,传统治疗方法仍存在各种缺陷,组织工程技术则为损伤软骨的修复治疗带来了新的希望,被视为能从根本上解决损伤软骨的修复的方法之一。随着技术的发展,近年来组织工程软骨的研究取得了长足的进步,并相继有一些产品进入临床研究阶段。本文就组织工程技术在软骨修复领域中的研究新进展作一综述。Cartilage injury caused by various causes such as trauma,inflammation,and degeneration is very common in clinic.Since the cartilage self-repair ability is extremely limited,the cartilage repair is an urgent problem in clinic.Nowadays,there are still some problems about the traditional treatments.Tissue-engineered cartilage is considered as a fundamental method for cartilage disease,and brings new hope for the repairmen of cartilage injury.With the development of technology,huge progress has been made about tissue-engineered cartilage in recent years.Some products have been entered the clinical research stage.This review following primary introduces the new progress about tissue-engineered cartilage.

关 键 词：组织工程软骨 种子细胞 支架 细胞因子 生物物理刺激 

分 类 号：R681.3[医药卫生—骨科学]