温敏型凝胶的缓释作用与临床应用  

Sustained-release effect and clinical application of thermosensitive gels

作　　者：陈泳佳 李彦林[1] 刘德建 何映红 杨骁[1] Chen Yongjia;Li Yanlin;Liu Dejian;He Yinghong;Yang Xiao(Department of Sports Medicine,First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan Provinee,China)

机构地区：[1]昆明医科大学第一附属医院运动医学科,云南省昆明市650032

出　　处：《中国组织工程研究》2020年第34期5428-5433,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81760403,81960409),项目负责人:李彦林;云南省自然科学基金重点项目[2017FE467(-007)],项目负责人:李彦林。

摘　　要：背景:温敏型凝胶是近年来兴起的一种药物新剂型,因其具有缓释、控释、靶向给药等优势而成为近年来的研究热点。目的:总结搜索文献中温敏型凝胶各种缓释机制,以及温敏型凝胶在临床上的应用疗效。方法:在万方、中国知网、维普、PubMed、谷歌学术等数据库中,以"温敏型凝胶,缓释,给药途径"为中文检索词,以"thermosensitive gel,sustained release,administration route"为英文检索词检索温敏型凝胶缓释机制及临床应用方面的文章。结果与结论:①温敏型凝胶具有最低临界溶解温度,能随环境温度改变而发生一定程度的相变,比其他剂型有更多的优势,能使药物在人体内发挥很好的缓释作用,降低药物毒性,防止药物外渗,并提高药物的稳定性,还具有很好的临床应用前景;②温敏型凝胶有着注射、口腔、耳内、鼻腔、眼内、皮肤等多种给药方式,具有广泛的应用前景。但是各种凝胶材料都存在不同缺点,比如天然生物材料具有可塑性差、机械强度不足、容易被病原微生物污染、难以大量生产的缺点,人工合成材料往往亲水性还不够,而且温敏型凝胶在体内的代谢途径对组织器官的影响也尚在研究中。BACKGROUND:Thermosensitive gel is a newly emerging drug type,which has been a popular area of research due to its advantages including sustained release,controlled release,and targeted drug delivery.OBJECTIVE:To summarize the various mechanisms underlying the sustained release of thermosensitive gels published in the literature,and its clinical application outcomes.METHODS:A retrieval of Wanfang,CNKI,VIP,PubMed,and Google Scholar was conducted using the search terms"thermosensitive gel,sustained release,administration route"in Chinese and English,respectively for the articles concerning sustained release mechanisms of thermosensitive gel and clinical applications.RESULTS AND CONCLUSION:(1)The thermosensitive gel possesses the lowest critical solution temperature and can change with the environment temperature changing to some extent.It has more advantages than other gels,and can lead to in vivo sustained release of drugs and reduce the toxicity,prevent drug extravasation,improve the stability of the drug,also has good clinical application prospects.(2)Thermosensitive gels have a variety of administration ways,such as injection,oral,in-ear,nasal cavity,intraocular,and skin,which has wide prospects.However,different kinds of gel materials have different shortcomings.Native biomaterials hold poor plasticity and mechanical strength,and are easy to be contaminated by pathogenic microorganisms,and cannot be prepared in large amounts.Besides,the hydrophilicity of synthetic materials is poor.Moreover,the effect of metabolic pathway of thermosensitive gel on tissues and organs is still under investigation.

关 键 词：温敏型凝胶 缓释作用 给药途径 生物利用度 凝胶制剂 注射给药 眼内给药 鼻腔给药 

分 类 号：R459.9[医药卫生—治疗学] R944.1[医药卫生—临床医学]