民族药九头狮子草治疗细菌性阴道炎有效部位的筛选研究  

Study on the active parts of Peristrophe japonica of bacterial vaginitis treatment effect

作　　者：范菊娣 钱志瑶 龙义国 覃容贵 FAN Judi;QIAN Zhiyao;LONG Yiguo;QIN Ronggui(School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang 550025,China;School of Public Health,Guizhou Medical University,Guiyang 550025,China;Department of Pathology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学药学院,贵阳550025 [2]贵州医科大学公共卫生学院,贵阳550025 [3]贵州医科大学附属医院病理科,贵阳550004

出　　处：《广州医药》2020年第3期21-25,46,共6页Guangzhou Medical Journal

基　　金：贵州省科技厅社会发展攻关项目(黔科合LG字[2011]030);贵州医科大学本科教学内容和课程体系改革项目(JG201971)。

摘　　要：目的筛选九头狮子草治疗小鼠细菌性阴道炎的有效部位。方法采用金黄色葡萄球菌、大肠埃希菌菌悬液注入小鼠阴道建立小鼠细菌性阴道炎动物模型,观察九头狮子草各极性部位对细菌性阴道炎的治疗作用。结果九头狮子草水提液、石油醚提取部位和70%乙醇提取部位对病原菌转阴率和阴道黏膜炎症的治愈程度均有提高,其中,对金黄色葡萄球菌的转阴率分别为60%、50%、40%,对大肠埃希菌的转阴率分别为80%、70%、50%。结论九头狮子草石油醚提取部位和70%乙醇提取部位为其治疗细菌性阴道炎的有效部位。Objective To study the active parts of Peristrophe japonica of vaginitis treatment effect.Methods The bacterial vaginitis model was established by injecting the bacteria of Staphylococcus aureus and Escherichia coli into the vagina of the mice and the treatment effect of each extract of Peristrophe japonica was observed.Results Three drug administration groups(including water extract of Peristrophe japonica,ligarine fraction and 70%ethanol fraction)showed marked treatment effect on the vaginitis models.The effect of water extract of Peristrophe japonica group were stronger than that of the ligarine fraction and 70%ethanol fraction groups.The pathogens seroconversion rates in Staphylococcus aureus were orderly as follows:60%,50%,40%.The pathogens seroconversion rates in Escherichia coli were orderly as follows:80%,70%,50%.Conclusion The ligarine fraction and 70%ethanol fraction of Peristrophe japonica might be the active extracts of curing vaginitis.

关 键 词：九头狮子草 模型 细菌性阴道炎 有效部位 

分 类 号：R29[医药卫生—民族医学]