探讨应用溶剂辅助研磨法制备非布索坦-烟酸系列新共晶  

The Preparation of Febuxostat-nicotinic Acid Series Cocrystal by Solvent-assisted Grinding

作　　者：张宪瑞 高蕾 Zhang Xianrui;Gao Lei(School of Chemical Engineering and Resource Recycling,Wuzhou University,Wuzhou 543000,China)

机构地区：[1]梧州学院化学工程与资源再利用学院,广西梧州543000

出　　处：《广东化工》2020年第11期27-28,共2页Guangdong Chemical Industry

基　　金：广西自然科学基金项目(2018GXNSFBA281167)资助;广西高校中青年教师科研基础能力提升项目(2019KY0700和2020KY17020)资助。

摘　　要：本文的目的是开发非布索坦新的固态化学形式,并期望能进一步改善非布索坦的溶解特性。本文利用溶剂辅助研磨法成功制备了两种非布索坦-烟酸系列新共晶,并通过红外、粉末X射线衍射和差示扫描量热法对其进行了理化性质表征。与非布索坦Z晶型相比较,非布索坦-异烟酸共晶表现出更高的热稳定性。The purpose of this paper is to develop the new solid-state chemical form of febuxostat,and to improve the solubility of febuxostat.In this paper,two new cocrystals of febuxostat were prepared by solvent-assisted grinding,and their physical and chemical properties were characterized by infrared spectroscopy,powder X-ray diffraction and differential scanning calorimetry.Compared with febuxostat(Polymorph Z),febuxostat-isonicotinic acid cocrystal showed higher thermal stability.

关 键 词：非布索坦 共晶 烟酸 △pKa 

分 类 号：O76[理学—晶体学]