沙芬酰胺盐酸盐和氢溴酸盐结晶过程工艺优化探究  

The Technology Optimization Research of the Crystallization Process of Safinamide Hydrochloride and Hydrobromide

作　　者：张宪瑞 解灵欣 沈亦婷 高蕾 Zhang Xianrui;Xie Lingxin;Shen Yiting;Gao Lei(School of Chemical Engineering and Resource Recycling,Wuzhou University,Wuzhou 543000,China)

机构地区：[1]梧州学院化学工程与资源再利用学院,广西梧州543000

出　　处：《广东化工》2020年第12期15-16,共2页Guangdong Chemical Industry

基　　金：广西自然科学基金项目(2018GXNSFBA281167)资助;广西高校中青年教师科研基础能力提升项目(2019KY0700和2020KY17020)资助;大学生创新创业训练计划项目资助(201811354097)。

摘　　要：设计和优化药物结晶过程是制药工程的重要步骤。本文通过对沙芬酰胺盐酸盐和氢溴酸盐结晶过程进行工艺优化,使沙芬酰胺盐酸盐和氢溴酸盐的总收率得到了提高,该工艺操作简单,节省了原料药,提高了生产率。The design and optimization of drug crystallization process is an important step in pharmaceutical engineering.In this paper,we have developed an improved method for the crystallization process of safinamide hydrochloride and hydrobromide.It increased the overall yield of safinamide hydrochloride and hydrobromide.The process is simple to operate,and saves the bulk drug and improves the productivity.

关 键 词：沙芬酰胺 盐酸盐 氢溴酸盐 结晶工艺 

分 类 号：O76[理学—晶体学]