2018年ICU革兰氏阴性菌的耐药情况分析  

Analysis of Drug Resistance of ICU Gram-negative Bacteria in 2018

作　　者：肖颖 邬剑[2] 纪洪兵 杨雪莹 张译如 谭振霞 王淑英[4] 李慧玲[1] Xiao Ying;Wu Jian;Ji Hongbing;Yang Xueying;Zhang Yiru;Tan Zhenxia;Wang Shuying;Li Huiling(The First Affiliated Hospital of Jiamusi University,Jiamusi 154003;Jiamusi Maternal and Child Health Hospital,Jiamusi 154004;Blood Station in Hegang City Center,Heilongjiang Province,Hegang 154101;Jiamusi University School of Basic Medicine,Jiamusi 154007,China)

机构地区：[1]黑龙江省佳木斯大学附属第一医院,黑龙江佳木斯154003 [2]佳木斯市妇幼保健院,黑龙江佳木斯154004 [3]黑龙江省鹤岗市中心血站,黑龙江鹤岗154101 [4]佳木斯大学基础医学院,黑龙江佳木斯154007

出　　处：《广东化工》2020年第12期56-57,44,共3页Guangdong Chemical Industry

基　　金：佳木斯大学校级课题,课题编号:S2014-0017;佳木斯大学教育科研课题,课题编号:JKA2012-009;黑龙江省卫生计生委科研课题,编号:2016-229;黑龙江中医药管理局科研课题,编号:ZHY16-018。

摘　　要：目的:分析我院2018年ICU科室革兰阴性菌耐药情况,为临床用药选择提供合理的参考。方法:收集我院ICU送检的细菌培养标本,采用仪器VITEK 2 Compact进行细菌鉴定和药敏试验,数据采用WHONET5.6软件对筛选的革兰阴性菌进行统计学分析。结果:2018年我院ICU共分离335株革兰阴性菌,常见的革兰阴性菌有肺炎克雷伯菌、鲍曼不动杆菌、大肠埃希菌、铜绿假单胞菌、阴沟肠杆菌。肺炎克雷伯菌、大肠埃希菌,阴沟肠杆菌对复方新诺明耐药率高,对头孢类耐药率较高,对亚胺培南和阿米卡星耐药率低。鲍曼不动杆菌对多种抗菌药呈现高耐药率。铜绿假单胞菌对所测的抗菌药的耐药率在18.18%~36.36%。结论:ICU院内革兰阴性菌耐药情况比较严峻,临床应当合理使用抗菌药物,加强细菌耐药的监测。Objective:To analyze the drug resistance of Gram-negative bacteria in the ICU department of our hospital in 2018,so as to provide a reasonable reference for clinical drug selection.Method:Collect the bacterial culture specimens sent by the ICU in our hospital,use the instrument VITEK 2 Compact for bacterial identification and drug susceptibility test,and the data were analyzed statistically with the NET negative software by WHONET5.6 software.Results:A total of 335 Gram-negative bacteria were isolated from ICU in 2018.Common Gram-negative bacteria include Klebsiella pneumoniae,Acinetobacter baumannii,Escherichia coli,Pseudomonas aeruginosa,and Enterobacter cloacae.Klebsiella pneumoniae,Escherichia coli,and Enterobacter cloacae have a high resistance rate to compound sinophenamine,a high resistance rate to cephalosporins,and a low resistance rate to imipenem and amikacin.Acinetobacter baumannii presents a high rate of resistance to various antibacterial drugs.The resistance rate of Pseudomonas aeruginosa to the tested antibacterial drugs is 18.18%~36.36%.Conclusion:The drug resistance of gram-negative bacteria in ICU hospitals is relatively severe.Antimicrobial drugs should be used rationally in clinic and the monitoring of bacterial drug resistance should be strengthened.

关 键 词：ICU 革兰阴性菌 耐药率 

分 类 号：TQ[化学工程]