咪达唑仑用于无创机械通气镇静30例分析  

Efficacy and Safety of Midazolam in 30 Patients with Noninvasive Mechanical Ventilation

作　　者：雷莉娟 邱栋发 陈亮 LEI Li-juan;QIU Dong-Fa;CHEN Liang(Department of Respiratory and Critical Care Medicine,Xiamen Changgeng Hospital,Xiamen 361026,China)

机构地区：[1]厦门长庚医院呼吸与危重症医学科,福建厦门361026

出　　处：《中国医药指南》2020年第18期80-81,共2页Guide of China Medicine

摘　　要：目的探讨咪达唑仑在无创通气镇静中应用的疗效及安全性。方法将60例无创通气患者随机分为2组,每组30例:咪达唑仑组给予咪达唑仑负荷量0.05 mg/kg,维持量0.004~0.006 mg/(kg·h);未镇静组未给镇静药。比较2组患者使用后不同时段心率、呼吸、平均动脉压、pH、二氧化碳分压等临床指标及辅助通气时间、气管插管率、谵妄发生率等。结果咪达唑仑组心率、呼吸、平均动脉压、pH、二氧化碳分压下降,优于未镇静组(P<0.05)。气管插管率、辅助通气时间及谵妄发生率均较未镇静组明显下降。结论适当镇静可以提高无创机械通气成功率。Objective To explore the efficacy and safety of midazolam in noninvasive ventilation.Methods 60 patients with noninvasive ventilation were randomly divided into 2 groups,30 cases in each group.The midazolam group was given 0.05 mg/kg,and the maintenance amount was 0.004-0.006 mg/(kg·h);There was no sedative in the non-sedation group.The patients in the two groups were compared by the following clinical indicators such as heart rate,respiration,average arterial pressure,PH,carbon dioxide partial pressure and other clinical indicators and auxiliary ventilation time,tracheal intubation rate,and delirium incidence.Results Midazolam group's heart rate,respiration,average arterial pressure,PH,and carbon dioxide partial pressure drop were better than those of non-sedation group(P<0.05).Additionally,the incidence of tracheal intubation,auxiliary ventilation time and delirium were signifi cantly lower than that in the non-sedation group.Conclusion Proper sedation can improve the success rate of noninvasive mechanical ventilation.

关 键 词：咪达唑仑 无创机械通气 镇静 

分 类 号：R614[医药卫生—麻醉学]